ID   ACSF_SYNPW              Reviewed;         360 AA.
AC   A5GKR3;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   25-NOV-2008, entry version 11.
DE   RecName: Full=Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase;
DE            Short=Mg-protoporphyrin IX monomethyl ester oxidative cyclase;
DE            EC=1.14.13.81;
GN   Name=acsF; OrderedLocusNames=SynWH7803_1102;
OS   Synechococcus sp. (strain WH7803).
OC   Bacteria; Cyanobacteria; Chroococcales; Synechococcus.
OX   NCBI_TaxID=32051;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Genoscope;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the formation of the isocyclic ring in
CC       chlorophyll biosynthesis. Mediates the cyclase reaction, which
CC       results in the formation of divinylprotochlorophyllide (Pchlide)
CC       characteristic of all chlorophylls from magnesium-protoporphyrin
CC       IX 13-monomethyl ester (MgPMME) (By similarity).
CC   -!- CATALYTIC ACTIVITY: Magnesium-protoporphyrin IX 13-monomethyl
CC       ester + NADPH + O(2) = 13(1)-hydroxy-magnesium-protoporphyrin IX
CC       13-monomethyl ester + NADP(+) + H(2)O.
CC   -!- CATALYTIC ACTIVITY: 13(1)-hydroxy-magnesium-protoporphyrin IX 13-
CC       monomethyl ester + NADPH + O(2) = 13(1)-oxo-magnesium-
CC       protoporphyrin IX 13-monomethyl ester + NADP(+) + 2 H(2)O.
CC   -!- CATALYTIC ACTIVITY: 13(1)-oxo-magnesium-protoporphyrin IX 13-
CC       monomethyl ester + NADPH + O(2) = divinylprotochlorophyllide +
CC       NADP(+) + 2 H(2)O.
CC   -!- COFACTOR: Iron (By similarity).
CC   -!- PATHWAY: Porphyrin biosynthesis; chlorophyll biosynthesis (light-
CC       independent).
CC   -!- SIMILARITY: Belongs to the acsF family.
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DR   EMBL; CT971583; CAK23528.1; -; Genomic_DNA.
DR   RefSeq; YP_001224825.1; -.
DR   GeneID; 5147809; -.
DR   GenomeReviews; CT971583_GR; SynWH7803_1102.
DR   KEGG; syx:SynWH7803_1102; -.
DR   GO; GO:0005506; F:iron ion binding; IEA:HAMAP.
DR   GO; GO:0048529; F:magnesium-protoporphyrin IX monomethyl este...; IEA:HAMAP.
DR   GO; GO:0015995; P:chlorophyll biosynthetic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0015979; P:photosynthesis; IEA:HAMAP.
DR   HAMAP; MF_01840; -; 1.
DR   InterPro; IPR008434; AcsF.
DR   InterPro; IPR003251; Rubrerythrin.
DR   Pfam; PF02915; Rubrerythrin; 1.
DR   TIGRFAMs; TIGR02029; AcsF; 1.
PE   3: Inferred from homology;
KW   Chlorophyll biosynthesis; Complete proteome; Iron; Metal-binding;
KW   NADP; Oxidoreductase; Photosynthesis.
FT   CHAIN         1    360       Magnesium-protoporphyrin IX monomethyl
FT                                ester [oxidative] cyclase.
FT                                /FTId=PRO_1000070553.
SQ   SEQUENCE   360 AA;  41422 MW;  66465D9F7D744B03 CRC64;
     MVPPTAVNDA PAAGSAVSVK DPAKDTILTP RFYTTDFEAM AAMDLRPNEA ELEAICEEFR
     KDYNRHHFVR NDEFEGAADK LDPETRRVFV EFLEQSCTSE FSGFLLYKEL SRRIKTRNPL
     LAECFAHMAR DEARHAGFLN KSMSDFGLQL DLGFLTANKS YTFFQPKFIF YATYLSEKIG
     YWRYITIFRH LEKNPDSKIF PIFNFFENWC QDENRHGDFF DALMKAQPNT VRGFRARLWC
     RFFLLAVFAT MYVRDVARKE FYEALGLDAR DYDRLVIDKT NETTARVFPV VLDVKNPKFY
     AGLENLVTNN AALDAVDASA SSAPIKVLRK LPHWIANGAQ MASLFLMAPV RSESFQPSVR
//