NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0609650104; PubMed=17372208 [NCBI, ExPASy, EBI, Israel, Japan]
Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L.;
"Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir.";
Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007).

Comments

FUNCTION: Reduction of activated sulfate into sulfite.
CATALYTIC ACTIVITY: Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin.
PATHWAY: Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the PAPS reductase family. CysH subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000557; ABO65771.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001124516.1; -.

3D structure databases

ModBase

A4IKB7.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004604;	Molecular function: phosphoadenylyl-sulfate reductase (thioredoxin) activity (inferred from electronic annotation from HAMAP).
GO:0019379;	Biological process: sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00063; -; 1.
PBIL [Tree]

InterPro

IPR011798; APS_reductase.
IPR004511; CysH.
IPR002500; PAPS_reduct.
IPR014729; Rossmann-like_a/b/a_fold.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.620; Rossmann-like_a/b/a_fold; 1.

Pfam

PF01507; PAPS_reduct; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR02055; APS_reductase; 1.
TIGR00434; cysH; 1.

BLOCKS

A4IKB7.

Genome annotation databases

GeneID

4965333; -.

GenomeReviews

CP000557_GR; GTNG_0389.

KEGG

gtn:GTNG_0389; -.

NMPDR

fig|420246.5.peg.374; -.

CMR

A4IKB7; GTNG_0389.

Other

ProtoNet

A4IKB7.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 235`	`235`		`Phosphoadenosine phosphosulfate reductase.`	`PRO_1000008927`

Sequence information

Length: 235 AA [This is the length of the unprocessed precursor]

Molecular weight: 27074 Da [This is the MW of the unprocessed precursor]

CRC64: DF680424DA1269A5 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLTYDRWETV EKPSFPSDNE TKGALDVLAW AYREYGDEIV YACSFGIEGI VLIDLISQVK 

        70         80         90        100        110        120 
PDAEIVFLDT GLHFQETYDT IAKVKETYPS LRIIMKQPHL TLEEQAAQFG DELWKRDPNK 

       130        140        150        160        170        180 
CCELRKVIPL REVLTGVTAW ISGLRREQSP TRRHVEYVNK DDKFRSIKVC PLIHWTWKDV 

       190        200        210        220        230 
WNYVYKHSLP YNVLHDRGYP SIGCAPCTAP ALDPNDLRSG RWAGQGKTEC GLHLT

A4IKB7 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools