FUNCTION: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes (By similarity).
CATALYTIC ACTIVITY: An aldehyde + NAD(P)⁺ + H₂O = an acid + NAD(P)H.
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the aldehyde dehydrogenase family.

Copyright

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Cross-references

Sequence databases

EMBL

EF382362; ABN70935.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001075889.1; -.

UniGene

Cfa.22321

3D structure databases

SMR

A3RF36; 4-448.

ModBase

A3RF36.

Family and domain databases

InterPro

IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR012394; Ald_DHase_NAD(P).
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.
PTHR11699:SF15; ALDH; 1.

Pfam

PF00171; Aldedh; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF036492; ALDH; 1.

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.

BLOCKS

A3RF36.

Genome annotation databases

GeneID

489526; -.

KEGG

cfa:489526; -.

Other

ProtoNet

A3RF36.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 453`	`453`	`Aldehyde dehydrogenase, dimeric NADP-preferring.`	`PRO_0000289586`
`NP_BIND`	`188 193`	`6`	`NAD (By similarity).`
`ACT_SITE`	`210 210`		`By similarity.`
`ACT_SITE`	`244 244`		`By similarity.`

Sequence information

Length: 453 AA [This is the length of the unprocessed precursor]

Molecular weight: 50713 Da [This is the MW of the unprocessed precursor]

CRC64: E986E2EF8D8AE46A [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSKISEVVQR ARAAFNSGKT RPLQFRIQQL EALRRMIKEH EKDLAGALTA DLHKNEWNAY 

        70         80         90        100        110        120 
YEEVVYVLEE IEYMIKKLPE WAADEPVEKT PQTQQDECYI HSEPLGVVLI IGTWNYPFTV 

       130        140        150        160        170        180 
TIQPMVGAIA AGNAVVIKPS ELSENMANLL ATIIPQYLDR DLYPVISGGI PETTELLKER 

       190        200        210        220        230        240 
FDHILYTGNT AVGKVIMMAA AKHLTPVTLE LGGKNPCYVD KDCDLDIACR RIAWGKFMNS 

       250        260        270        280        290        300 
GQTCVAPDYI LCDPSIQNQI VEKLKKALKE FYGEDAKKSR DYGRIINSRH FQRVMGLMEG 

       310        320        330        340        350        360 
QKVAYGGTGD AATRYIAPTI LIDVDTQSQV MQEEIFGPVM PIVCVRSLEE AIQFINQREK 

       370        380        390        400        410        420 
PLALYVFSLN DKMIKKMIAE TSSGGVTAND VIVHVSVHSL PYGGVGNSGM GSYHGKKSFE 

       430        440        450 
TFSHCRSCLV RPLLNDESLK TRYPPSLAKM TRH

A3RF36 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools