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UniProtKB/Swiss-Prot entry A2X8W3


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HMDH1_ORYSI
Primary accession number A2X8W3
Secondary accession number P48019
Integrated into Swiss-Prot on July 24, 2007
Sequence was last modified on July 24, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 13)
Name and origin of the protein
Protein name 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
Synonyms HMG-CoA reductase 1
EC 1.1.1.34
Gene name
Name: HMG1
ORFNames: OsI_008506
From
Oryza sativa subsp. indica (Rice) [TaxID: 39946] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP clade; Ehrhartoideae; Oryzeae; Oryza.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=cv. IR36;
DOI=10.1007/BF00043869; PubMed=8049366 [NCBI, ExPASy, EBI, Israel, Japan]
Nelson A.J., Doerner P.W., Zhu Q., Lamb C.J.;
"Isolation of a monocot 3-hydroxy-3-methylglutaryl coenzyme A reductase gene that is elicitor-inducible.";
Plant Mol. Biol. 25:401-412(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. 93-11;
DOI=10.1371/journal.pbio.0030038; PubMed=15685292 [NCBI, ExPASy, EBI, Israel, Japan]
Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L., Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
"The genomes of Oryza sativa: a history of duplications.";
PLoS Biol. 3:266-281(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L28995; AAA21720.1; ALT_FRAME; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CM000127; EAY87273.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S46314; S46314.
3D structure databases
HSSP P04035; 1DQA. [HSSP ENTRY / PDB]
ModBase A2X8W3.
Organism-specific databases
Gramene P48019; -.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR002202; HMG_CoA_Rdtase_cat.
IPR004554; HMG_CoA_Rdtase_I_cat.
Graphical view of domain structure.
PANTHER PTHR10572; HMG-CoA_red; 1.
Pfam PF00368; HMG-CoA_red; 1.
Pfam graphical view of domain structure.
PRINTS PR00071; HMGCOARDTASE.
TIGRFAMs TIGR00533; HMG_CoA_R_NADP; 1.
PROSITE PS00066; HMG_COA_REDUCTASE_1; 1.
PS00318; HMG_COA_REDUCTASE_2; 1.
PS01192; HMG_COA_REDUCTASE_3; 1.
PS50065; HMG_COA_REDUCTASE_4; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS A2X8W3.
Other
ProtoNet A2X8W3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Endoplasmic reticulum; Glycoprotein; Isoprene biosynthesis; Membrane; NADP; Oxidoreductase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   539  539     3-hydroxy-3-methylglutaryl-coenzyme A reductase 1. PRO_0000295657
TRANSMEM   63    83  21     Potential. 
TRANSMEM   496   516  21     Potential. 
REGION   84   124  41     Linker (By similarity). 
REGION   125   539  415     Catalytic (By similarity). 
ACT_SITE   218   218        Charge relay system (By similarity). 
ACT_SITE   350   350        Charge relay system (By similarity). 
ACT_SITE   426   426        Charge relay system (By similarity). 
ACT_SITE   524   524        Proton donor (By similarity). 
CARBOHYD   282   282        N-linked (GlcNAc...) (Potential). 
CARBOHYD   528   528        N-linked (GlcNAc...) (Potential). 
CONFLICT   48    48        L -> V (in Ref. 1; AAA21720). 
CONFLICT   104   108        RPAAA -> APP (in Ref. 1; AAA21720). 
CONFLICT   123   123        A -> G (in Ref. 1; AAA21720). 
CONFLICT   257   258        SA -> CP (in Ref. 1; AAA21720). 
CONFLICT   444   444        D -> N (in Ref. 1; AAA21720). 
CONFLICT   494   494        K -> G (in Ref. 1; AAA21720). 
Sequence information
Length: 539 AA [This is the length of the unprocessed precursor] Molecular weight: 56331 Da [This is the MW of the unprocessed precursor] CRC64: 031F08C2671B910E [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDVRRGGGGG RIVGAARRAL TWGALPLPMR ITNGLAMVSL VLSSCDLLRL CSDRERPLGG 

        70         80         90        100        110        120 
REFATVVCQL ASVVYLLSLF AHPDAPATTT GDDDDGQGGS RRARPAAAEP APMHGHGGGM 

       130        140        150        160        170        180 
MEADDEEIVA AVASGALPSH RLESRLGDCR RAARLRREAL RRVTGRGVEG LPFDGMDYQA 

       190        200        210        220        230        240 
ILGQCCEMPV GYVQLPVGVA GPLLLDGREY HVPMATTEGC LVASVNRGCR AISASGGAFS 

       250        260        270        280        290        300 
VLLRDAMSRA PAVKLPSAMR AAELKAFAEA PANFELLAAV FNRSSRFGRL QDIRCALAGR 

       310        320        330        340        350        360 
NLYMRFSCIT GDAMGMNMVS KGVENVLGYL QNVFPDMDVI SVSGNYCSDK KPTAVNWIEG 

       370        380        390        400        410        420 
RGKSVVCEAI IKGDVVQKVL KTTVEKLVEL NIIKNLAGSA VAGALGGFNA HASNIVTALF 

       430        440        450        460        470        480 
IATGQDPAQN VESSQCITML EEVDDGDDLH ISVTMPSIEV GTIGGGTCLA SQAACLNLLG 

       490        500        510        520        530 
VKGSNHGSPG ANAKRLATIV AGSVLAGELS LLAALASGHL VKSHMMYNRS SKDVAKAAS 

A2X8W3 in FASTA format

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