[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K.; "Bifidobacterium adolescentis complete genome sequence."; Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity).
CATALYTIC ACTIVITY: L-glutamate 5-semialdehyde + phosphate + NADP⁺ = L-glutamyl 5-phosphate + NADPH.
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the gamma-glutamyl phosphate reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AP009256; BAF39682.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_909764.1; -.

3D structure databases

ModBase

A1A1U9.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004350;	Molecular function: glutamate-5-semialdehyde dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0006561;	Biological process: proline biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00412; -; 1.
PBIL [Tree]

InterPro

IPR016163; Ald_DHase_C.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR000965; Gglut_pp_reduct.
IPR012134; Glu-5-SA_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.309.10; Aldehyde_dehydrogenase_C; 1.
G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11063:SF1; GSA_DH; 1.

Pfam

PF00171; Aldedh; 1.
Pfam graphical view of domain structure.

PIRSF000151; GPR; 1.

TIGR00407; proA; 1.

PS01223; PROA; 1.

Genome annotation databases

GeneID

4556586; -.

GenomeReviews

AP009256_GR; BAD_0901.

KEGG

bad:BAD_0901; -.

NMPDR

fig|1680.3.peg.1171; -.

CMR

A1A1U9; BAD_0901.

Other

ProtoNet

A1A1U9.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Proline biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 427`	`427`		`Gamma-glutamyl phosphate reductase.`	`PRO_0000340873`

Sequence information

Length: 427 AA [This is the length of the unprocessed precursor]

Molecular weight: 45480 Da [This is the MW of the unprocessed precursor]

CRC64: 3DF4BACCB17513E4 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNADVFEAVC AMGDAARTAQ SQLAQANTEA KNQLLNAIAD ALDQHADDIA AANTLDMNKA 

        70         80         90        100        110        120 
ETDGMDAGKL DRLKFDQQRI TAAAQGVRHV ASLPDPIGEI VRGYHLENGL RLQQVRVPIG 

       130        140        150        160        170        180 
VLGMIYEARP NVTVDVASLC IKSGNAVLLR GGHAAEHTNA ATLAVIADVL TKHGYDHNMI 

       190        200        210        220        230        240 
ATVDQYGRDG ATAMMEARGH IDVLIPRGGA GLIQAVVRNS KVPVIETGAG NVHIYVDRTG 

       250        260        270        280        290        300 
NPDKAIPILI NAKTQRVGVC NATEKLLVHK DIAESFLPKA AAALAAAGVE MHADERAYGI 

       310        320        330        340        350        360 
IEHAGIANAQ LVHATDEDWD TEYLALKIGI KVVDSLDEAI AHINRHSTGH TESIIAEDYS 

       370        380        390        400        410        420 
AIEEFTARID SAVVMVNAST RFTDGGVFGF GAELGISTQK MHARGPMGLH EMTTTKWIGY 


GTGQVRE

A1A1U9 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools