[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.; Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde to succinate. Although it has succinate semialdehyde dehydrogenase activity, is likely to act physiologically on a different aldehyde(s) (By similarity).
CATALYTIC ACTIVITY: Succinate semialdehyde + NAD(P)⁺ + H₂O = succinate + NAD(P)H.
SIMILARITY: Belongs to the aldehyde dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000480; ABK69825.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_890138.1; -.

3D structure databases

ModBase

A0R4Q0.

Ontologies

GO:0009013;	Molecular function: succinate-semialdehyde dehydrogenase [NAD(P)+] activity (inferred from electronic annotation from EC).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.

Pfam

PF00171; Aldedh; 1.
Pfam graphical view of domain structure.

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS; FALSE_NEG.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.

Genome annotation databases

GeneID

4534217; -.

GenomeReviews

CP000480_GR; MSMEG_5912.

KEGG

msm:MSMEG_5912; -.

NMPDR

fig|246196.1.peg.5871; -.

TIGR

MSMEG_5912; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 517`	`517`	`Putative succinate-semialdehyde dehydrogenase [NADP+].`	`PRO_0000310710`
`NP_BIND`	`232 237`	`6`	`NAD or NADP (By similarity).`
`ACT_SITE`	`254 254`		`By similarity.`
`ACT_SITE`	`288 288`		`By similarity.`

Sequence information

Length: 517 AA [This is the length of the unprocessed precursor]

Molecular weight: 54992 Da [This is the MW of the unprocessed precursor]

CRC64: 8015E38D33E866C4 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MPAPSAADFA RLRSLVAIED LDARQSRPIE EVFTGRELTT IPVGTAEDVA AAFAKARAAQ 

        70         80         90        100        110        120 
RGWAHRPVAE RAAIMERFRD LVAKNRDFLM DVAQAETGKA RSAAQEEIVD MMLNARYYAR 

       130        140        150        160        170        180 
QAVKLLAPKR VQGLLPGVVK TVVNHHPKGV VGVISPWNYP MALSISDSIP ALLAGNAVVV 

       190        200        210        220        230        240 
KPDSQTPYCT LANAELLYEA GLPRDLFAVV PGPGSVVGTA IVENCDYLMF TGSTATGRTL 

       250        260        270        280        290        300 
AEQCGRRLIG FSAELGGKNP MIVTRGAKLD VAAKAATRAC FSNAGQLCIS IERIYVERAV 

       310        320        330        340        350        360 
ADEFTAKFGE QVRSMRLAAT YDFTADMGSL ISEDQIKTVS GHVDDAKAKG ATVIAGGNIR 

       370        380        390        400        410        420 
PDIGPRFYEP TVLTGVTDEM ECARNETFGP VVSIYPVESV AEAIEKANDT EYGLNASVWA 

       430        440        450        460        470        480 
GSKTEGEAIA AQLQAGTVNV DEGYALAFGS TAAPMGGMKA SGVGRRHGAD GILKYTESQT 

       490        500        510 
VATSRVLNLD PPLGISGTLW QKAMTPMIRA VQKLPGR

A0R4Q0 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools