[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.; Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde to succinate. It is believed to be the main source of succinate semialdehyde dehydrogenase activity in Mycobacterium (By similarity).
CATALYTIC ACTIVITY: Succinate semialdehyde + NAD(P)⁺ + H₂O = succinate + NAD(P)H.
SIMILARITY: Belongs to the aldehyde dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000479; ABK64449.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_884057.1; -.

3D structure databases

ModBase

A0QMB9.

Family and domain databases

InterPro

IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.

Pfam

PF00171; Aldedh; 1.
Pfam graphical view of domain structure.

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; FALSE_NEG.

BLOCKS

A0QMB9.

Genome annotation databases

GeneID

4526409; -.

GenomeReviews

CP000479_GR; MAV_4936.

KEGG

mav:MAV_4936; -.

TIGR

MAV_4936; -.

Other

ProtoNet

A0QMB9.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; NADP; Oxidoreductase; Tricarboxylic acid cycle.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 472`	`472`	`Succinate-semialdehyde dehydrogenase [NADP+].`	`PRO_0000310700`
`NP_BIND`	`210 215`	`6`	`NAD or NADP (By similarity).`
`ACT_SITE`	`232 232`		`By similarity.`
`ACT_SITE`	`266 266`		`By similarity.`

Sequence information

Length: 472 AA [This is the length of the unprocessed precursor]

Molecular weight: 50010 Da [This is the MW of the unprocessed precursor]

CRC64: 39C4E3CBCDD495C5 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MPIATINPAT GETVKTFTPA SDAEVDAAIA RAYERFLDYR HSTTFAQRAQ WANATADLLE 

        70         80         90        100        110        120 
AEADEVAAMM TLEMGKTLKS AKAEALKCAK GFRYYAQNAE QLLADEPADA GKVGAARAYI 

       130        140        150        160        170        180 
RYQPLGVVLA VMPWNFPLWQ AVRFAAPALM AGNVGILKHA SNVPQSALYL ADVITRGGFP 

       190        200        210        220        230        240 
EGCFQTLLVP SSAVERILRD PRVAAATLTG SEPAGQSVAA IAGDEIKPTV LELGGSDPFI 

       250        260        270        280        290        300 
VMPSADLDEA VKTAVTARVQ NNGQSCIAAK RFIVHTDIYD TFVDKFVEQM KALKVGDPTD 

       310        320        330        340        350        360 
PATDVGPLAT ESGRDEIAKQ VDDAVAAGAT LRCGGKPLDG PGWFYPPTVV TDITKDMALY 

       370        380        390        400        410        420 
TEEVFGPVAS MYRAADIDEA IEIANATTFG LGSNAWTNDA AEQQRFIDDI EAGQVFINGM 

       430        440        450        460        470 
TVSYPELGFG GVKRSGYGRE LAGLGIRAFC NAKTVWIGSS KSGDAGGGSK VE

A0QMB9 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools