FUNCTION: Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
CATALYTIC ACTIVITY: L-glutamate 5-semialdehyde + phosphate + NADP⁺ = L-glutamyl 5-phosphate + NADPH.
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the gamma-glutamyl phosphate reductase family.

Copyright

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Cross-references

Sequence databases

EMBL

CP000462; ABK38804.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_857909.1; -.

3D structure databases

ModBase

A0KNQ8.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004350;	Molecular function: glutamate-5-semialdehyde dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0006561;	Biological process: proline biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00412; -; 1.
PBIL [Tree]

InterPro

IPR016163; Ald_DHase_C.
IPR000965; Gglut_pp_reduct.
IPR012134; Glu-5-SA_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.309.10; Aldehyde_dehydrogenase_C; 1.

PANTHER

PTHR11063:SF1; GSA_DH; 1.

PIRSF000151; GPR; 1.

TIGR00407; proA; 1.

PS01223; PROA; 1.

Genome annotation databases

GeneID

4487146; -.

GenomeReviews

CP000462_GR; AHA_3420.

KEGG

aha:AHA_3420; -.

TIGR

AHA_3420; -.

Other

ProtoNet

A0KNQ8.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Proline biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 417`	`417`		`Gamma-glutamyl phosphate reductase.`	`PRO_1000049932`

Sequence information

Length: 417 AA [This is the length of the unprocessed precursor]

Molecular weight: 44328 Da [This is the MW of the unprocessed precursor]

CRC64: 3D9241D61B0E51CF [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSLEKMGQAA REAAYQLATV STAQKNRALA AIADELEARS HQILAANEKD IAAGRAAGLS 

        70         80         90        100        110        120 
DAMLDRLLLN PARLAGIVAD VRKVISLDDP VGAEIDSRVL ENGLRLSRRR VPIGVIGVIY 

       130        140        150        160        170        180 
EARPNVTIDI ASLCLKTGNA SILRGGRETF HSNLELVRVI QSALAASGLP RDAVQYIDNP 

       190        200        210        220        230        240 
DRALVGELLR LDRYVDMIIP RGGAGLHKMC KENSSIPVII GGFGISHIFV DESADLARSL 

       250        260        270        280        290        300 
AVIDNAKVQR PSACNALDSL LVHEKVAATL LPQLVGLMNE RKVALVATPE AMPLLAGADS 

       310        320        330        340        350        360 
LRAAGPEDFD TEWLSLTLGV KLVADVNEAL AHMREHNAGH SDAILTNDLA NAERFVNGAG 

       370        380        390        400        410 
SAAVYVNAST RFTDGGQFGL GAEVAVSTQM LHARGPMGLT ELTSYKWVGL ADYLSRA

A0KNQ8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools