Species code:	CLOK5
Taxonomy:	Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium (TaxID: 431943) [NEWT/ NCBI]
Description:	Clostridium kluyveri is a Gram-positive, spore-forming bacterium. It is unique among the clostridia as it grows anaerobically on ethanol and acetate as sole energy sources, and has been extensively studied. Fermentation products are butyrate, caproate, and H2. It has been used as a source of enzymes, for example phosphotransacetylase for analytical purposes and enoate reductases for stereospecific hydrogenation reactions. A membrane-bound energy-converting NADH:ferredoxin oxidoreductase and a butyryl-CoA dehydrogenase complex coupling the reduction of crotonyl-CoA to butyryl-CoA with the reduction of ferredoxin represent a new energy-conserving module in anaerobes. The genes for NAD-dependent ethanol dehydrogenase and NAD(P)-dependent acetaldehyde dehydrogenase are located next to genes for microcompartment proteins, suggesting that the two enzymes, which are isolated together in a macromolecular complex, form a carboxysome-like structure. Unique for a strict anaerobe, C. kluyveri harbors three sets of genes predicted to encode for polyketide/nonribosomal peptide synthetase hybrides and one set for a nonribosomal peptide synthetase. The latter is predicted to catalyze the synthesis of a new siderophore, which is formed under iron-deficient growth conditions (modified from PubMed:18218779).
Properties:	Presence of flagella: not known Interaction: No Number of membranes: 1 Number of inteins:0
Statistics:	Number of CLOK5 entries in the UniProt Knowledgebase: 3828 (251 in UniProtKB/Swiss-Prot + 3577 in UniProtKB/TrEMBL)

Genome structure:	• Chromosome EMBL accession number CP000673 (circular; 3,964,618 bp) (download entry) (download Genome Reviews). • Plasmid pCKL555A EMBL accession number CP000674 (circular; 59,182 bp) (download entry) (download Genome Reviews).
Reference(s):	[1] PubMed=18218779; [ NCBI , EBI , Israel , Japan ] Seedorf H., Fricke W.F., Veith B., Brueggemann H., Liesegang H., Strittmatter A., Miethke M., Buckel W., Hinderberger J., Li F., Hagemeier C., Thauer R.K., Gottschalk G. ; "The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features."; Proc. Natl. Acad. Sci. U.S.A. 105:2128-2133(2008).
Web links:	Official genome site(s): http://www.g2l.bio.uni-goettingen.de/ Other web sites: ClostriDB: http://xbase.bham.ac.uk/clostridb/genome.pl?id=1030 Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=19065 GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Cklu_DSM555  EBI Proteome Analysis page

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