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PROSITE documentation PDOC00375

Bacterial quinoprotein dehydrogenases signatures

Description:

Pyrrolo-quinoline quinone (PQQ) is redox coenzyme, which serves as a cofactor for a number of enzymes (quinoproteins) and particularly for some bacterial dehydrogenases [1,2]. A number of these bacterial quinoproteins are clearly evolutionary related. These proteins are listed below.

These dehydrogenases all have from 600 to 800 amino acids. We developed two signature patterns for these proteins using sequence data from well conserved regions: the first one is located in the N-terminal half while the second one is from the C-terminal half.

Last update:

December 2004 / Patterns and text revised.

Technical section:

PROSITE methods (with tools and information) covered by this documentation:

BACTERIAL_PQQ_1, PS00363; Bacterial quinoprotein dehydrogenases signature 1  (PATTERN)
Consensus pattern: [DEN] - [WV] - x(3) - G - [RKNM] - x(6) - [FYW] - [SV] - x(4) - [LIVM] - N - x(2) - N - V - x(2) - L - [RKT]
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: NONE.
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00363
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00363
• Scan Swiss-Prot/TrEMBL entries against PS00363
• view ligand binding statistics
Matching PDB structures: 1FLG 1H4I 1H4J 1LRW ... [ALL]
BACTERIAL_PQQ_2, PS00364; Bacterial quinoprotein dehydrogenases signature 2  (PATTERN)
Consensus pattern: W - x(4) - [YF] - D - x(3) - [DN] - [LIVMFYT] - [LIVMFY](3) - x(2) - G - x(2) - [STAG] - [PVT]
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: NONE.
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00364
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00364
• Scan Swiss-Prot/TrEMBL entries against PS00364
• view ligand binding statistics
Matching PDB structures: 1FLG 1G72 1H4I 1H4J ... [ALL]

References:

1 AuthorsDuine J.A., Jongejan J.A.
TitleQuinoproteins, enzymes with pyrrolo-quinoline quinone as cofactor.
SourceAnnu. Rev. Biochem. 58:403-426(1989).
PubMed ID2549854
DOI10.1146/annurev.bi.58.070189.002155
2 AuthorsGallop P.M., Paz M.A., Flueckiger R., Kagan H.M.
TitlePQQ, the elusive coenzyme.
SourceTrends Biochem. Sci. 14:343-346(1989).
PubMed ID2572081
3 AuthorsInoue T., Sunagawa M., Mori A., Imai C., Fukuda M., Takagi M., Yano K.
TitleCloning and sequencing of the gene encoding the 72-kilodalton dehydrogenase subunit of alcohol dehydrogenase from Acetobacter aceti.
SourceJ. Bacteriol. 171:3115-3122(1989).
PubMed ID2722742
4 AuthorsCleton-Jansen A.-M., Dekker S., van de Putte P., Goosen N.
SourceMol. Gen. Genet. 229:206-212(1991).

Copyright:

This PROSITE entry is copyright by the Swiss Institute of Bioinformatics (SIB). There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://www.isb-sib.ch/announce/or email to license@isb-sib.ch).

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