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NiceZyme View of ENZYME: EC 3.4.21.89

Official Name
Signal peptidase I.
Alternative Name(s)
Bacterial leader peptidase I.
Phage-procoat-leader peptidase.
SPase I.
Reaction catalysed
Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins
Comment(s)
  • Unaffected by inhibitors of most serine peptidases, but site-directed mutagenesis implicates a Ser/Lys catalytic dyad in activity.
  • Cleaves a single bond -Ala-|-Ala- in M13 phage procoat protein, producing free signal peptide and coat protein.
  • Eukaryote signal peptidases that may have somewhat different specificity are known from the endoplasmic reticulum membrane and mitochondrial inner membrane.
  • Belongs to peptidase family S26.
  • Formerly EC 3.4.99.36.
Cross-references
Biochemical Pathways; map number(s)M3 ; R4
PROSITEPDOC00418
BRENDA3.4.21.89
PUMA23.4.21.89
PRIAM enzyme-specific profiles3.4.21.89
KEGG Ligand Database for Enzyme Nomenclature3.4.21.89
IUBMB Enzyme Nomenclature3.4.21.89
IntEnz3.4.21.89
MEDLINEFind literature relating to 3.4.21.89
MetaCyc3.4.21.89
UniProtKB/Swiss-Prot
P41026, LEP1_BACAM;  P72660, LEP1_SYNY3;  P41025, LEP2_BACAM;  
P73157, LEP2_SYNY3;  P37943, LEPP_BACNA;  Q57350, LEPQ_BACNA;  
P28628, LEPS_BACSU;  P71013, LEPT_BACSU;  P42959, LEPU_BACSU;  
O07560, LEPV_BACSU;  P54506, LEPW_BACSU;  O67088, LEP_AQUAE;  
P41027, LEP_BACCL;  P42668, LEP_BACLI;  P57347, LEP_BUCAI;  
Q8K9R0, LEP_BUCAP;  Q89AM6, LEP_BUCBP;  P00803, LEP_ECOLI;  
P44454, LEP_HAEIN;  Q9ZLQ5, LEP_HELPJ;  O25300, LEP_HELPY;  
O33021, LEP_MYCLE;  Q10789, LEP_MYCTU;  Q51876, LEP_PHOLA;  
Q9I5G7, LEP_PSEAE;  P26844, LEP_PSEFL;  A8GM78, LEP_RICAH;  
A8GYE1, LEP_RICB8;  Q1RHA1, LEP_RICBR;  A8EXI2, LEP_RICCK;  
Q92JB1, LEP_RICCN;  Q4UKA7, LEP_RICFE;  A8F0M1, LEP_RICM5;  
Q9ZE32, LEP_RICPR;  A8GQT7, LEP_RICRS;  Q8L2J7, LEP_RICTY;  
P0A1W3, LEP_SALTI;  P0A1W2, LEP_SALTY;  Q5HHB9, LEP_STAAC;  
P0A067, LEP_STAAM;  P0A068, LEP_STAAN;  Q6GIC3, LEP_STAAR;  
Q6GAW1, LEP_STAAS;  P0A070, LEP_STAAU;  P0A069, LEP_STAAW;  
O07344, LEP_STRPN;  P59662, LEP_STRR6;  Q8H0W1, PLSP1_ARATH;  
O04348, TPP1_ARATH;  Q9M9Z2, TPP2_ARATH;  

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