| Official Name |
|---|
| Subtilisin.
|
| Reaction catalysed |
|---|
| Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides |
| Comment(s) |
|---|
- Subtilisin is a serine endopeptidase that evolved independently of
chymotrypsin.
- It contains no cysteine residues (although these are found in
homologous enzymes).
- Species variants include subtilisin BPN' (also subtilisin B,
subtilopeptidase C, nagarse, nagarse proteinase, subtilisin Novo,
bacterial proteinase Novo) and subtilisin Carlsberg (subtilisin A,
subtilopeptidase A, alcalase Novo).
- Similar enzymes are produced by various Bacillus subtilis strains and
other Bacillus species.
- Belongs to peptidase family S8.
- Formerly EC 3.4.4.16 and EC 3.4.21.14.
|
| Cross-references |
|---|
| PROSITE | PDOC00125 |
| BRENDA | 3.4.21.62 |
| PUMA2 | 3.4.21.62 |
| PRIAM enzyme-specific profiles | 3.4.21.62 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.62 |
| IUBMB Enzyme Nomenclature | 3.4.21.62 |
| IntEnz | 3.4.21.62 |
| MEDLINE | Find literature relating to 3.4.21.62 |
| MetaCyc | 3.4.21.62 |
| UniProtKB/Swiss-Prot |
| P29599, SUBB_BACLE; | P00781, SUBD_BACLI; | P35835, SUBN_BACNA; |
| P29600, SUBS_BACLE; | P00782, SUBT_BACAM; | P00780, SUBT_BACLI; |
| P07518, SUBT_BACPU; | P28842, SUBT_BACS9; | P00783, SUBT_BACSA; |
| P29142, SUBT_BACST; | P04189, SUBT_BACSU; |
|
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