| Official Name |
|---|
| Alpha-ribazole phosphatase.
|
| Reaction catalysed |
|---|
| Alpha-ribazole 5'-phosphate + H(2)O <=> alpha-ribazole + phosphate |
| Comment(s) |
|---|
- In Salmonella typhimurium LT2, under anaerobic conditions, CobU
(EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21),
CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyze reactions in the
nucleotide loop assembly pathway, which convert adenosylcobinamide
(AdoCbi) into adenosylcobalamin (AdoCbl).
- CobT and CobC are involved in 5,6-dimethylbenzimidazole activation
whereby 5,6-dimethylbenzimidazole is converted to its riboside,
alpha-ribazole.
- The second branch of the nuclotide loop assembly pathway is the
cobinamide (Cbi) activation branch where AdoCbi or
adenosylcobinamide-phosphate is converted to the activated
intermediate AdoCbi-GDP by the bifunctional enzyme CobU.
- CobS catalyzes the final step in adenosylcobalamin biosynthesis,
which is the condensation of AdoCbi-GDP with alpha-ribazole to yield
adenosylcobalamin.
|
| Cross-references |
|---|
| BRENDA | 3.1.3.73 |
| PUMA2 | 3.1.3.73 |
| PRIAM enzyme-specific profiles | 3.1.3.73 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.1.3.73 |
| IUBMB Enzyme Nomenclature | 3.1.3.73 |
| IntEnz | 3.1.3.73 |
| MEDLINE | Find literature relating to 3.1.3.73 |
| MetaCyc | 3.1.3.73 |
| UniProtKB/Swiss-Prot |
|
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