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NiceZyme View of ENZYME: EC 3.1.3.67

Official Name
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase.
Alternative Name(s)
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase.
Reaction catalysed
Phosphatidylinositol 3,4,5-trisphosphate + H(2)O <=> phosphatidylinositol 4,5-bisphosphate + phosphate
Cofactor(s)
Magnesium.
Comment(s)
  • Does not dephosphorylate inositol 4,5-bisphosphate.
  • This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyzes Ins(1,3,4,5)P(4) to Ins(1,4,5)P(3).
Cross-references
BRENDA3.1.3.67
PUMA23.1.3.67
PRIAM enzyme-specific profiles3.1.3.67
KEGG Ligand Database for Enzyme Nomenclature3.1.3.67
IUBMB Enzyme Nomenclature3.1.3.67
IntEnz3.1.3.67
MEDLINEFind literature relating to 3.1.3.67
MetaCyc3.1.3.67
UniProtKB/Swiss-Prot
P60483, PTEN_CANFA;  P60484, PTEN_HUMAN;  O08586, PTEN_MOUSE;  
O94526, PTEN_SCHPO;  Q9PUT6, PTEN_XENLA;  P53916, TEP1_YEAST;  
Q6XPS3, TPTE2_HUMAN;  Q4R6N0, TPTE2_MACFA;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
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