| Official Name |
|---|
| Sarcosine/dimethylglycine N-methyltransferase.
|
| Alternative Name(s) |
|---|
| ApDMT. |
| Sarcosine dimethylglycine N-methyltransferase. |
| Sarcosine-dimethylglycine methyltransferase. |
| SDMT. |
| Reaction catalysed |
|---|
- S-adenosyl-L-methionine + sarcosine <=> S-adenosyl-L-homocysteine + N,N-dimethylglycine
- S-adenosyl-L-methionine + N,N-dimethylglycine <=> S-adenosyl-L-homocysteine + betaine
|
| Comment(s) |
|---|
- Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece
halophytica synthesize betaine from glycine by a three-step
methylation process.
- The first enzyme, EC 2.1.1.156, leads to the formation of either
sarcosine or N,N-dimethylglycine, which is further methylated to
yield betaine (N,N,N-trimethylglycine) by the action of this enzyme.
- Both of these enzymes can catalyze the formation of
N,N-dimethylglycine from sarcosine.
- The reactions are strongly inhibited by S-adenosyl-L-homocysteine.
|
| Cross-references |
|---|
| BRENDA | 2.1.1.157 |
| PUMA2 | 2.1.1.157 |
| PRIAM enzyme-specific profiles | 2.1.1.157 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.157 |
| IUBMB Enzyme Nomenclature | 2.1.1.157 |
| IntEnz | 2.1.1.157 |
| MEDLINE | Find literature relating to 2.1.1.157 |
| MetaCyc | 2.1.1.157 |
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