ID   2.1.1.156
DE   Glycine/sarcosine N-methyltransferase.
AN   Glycine sarcosine N-methyltransferase.
AN   Glycine-sarcosine methyltransferase.
AN   GMT.
AN   GSMT.
CA   (1) S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine +
CA   sarcosine.
CA   (2) S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine +
CA   N,N-dimethylglycine.
CC   -!- Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece
CC       halophytica synthesize betaine from glycine by a three-step
CC       methylation process.
CC   -!- This is the first enzyme and it leads to the formation of either
CC       sarcosine or N,N-dimethylglycine, which is further methylated to
CC       yield betaine (N,N,N-trimethylglycine) by the action of EC 2.1.1.157.
CC   -!- Differs from EC 2.1.1.20, as it can further methylate the product of
CC       the first reaction.
CC   -!- Acetate, dimethylglycine and S-adenosyl-L-homocysteine can inhibit
CC       the reaction.
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