| Official Name |
|---|
| Glycine/sarcosine N-methyltransferase.
|
| Alternative Name(s) |
|---|
| Glycine sarcosine N-methyltransferase. |
| Glycine-sarcosine methyltransferase. |
| GMT. |
| GSMT. |
| Reaction catalysed |
|---|
- S-adenosyl-L-methionine + glycine <=> S-adenosyl-L-homocysteine + sarcosine
- S-adenosyl-L-methionine + sarcosine <=> S-adenosyl-L-homocysteine + N,N-dimethylglycine
|
| Comment(s) |
|---|
- Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece
halophytica synthesize betaine from glycine by a three-step
methylation process.
- This is the first enzyme and it leads to the formation of either
sarcosine or N,N-dimethylglycine, which is further methylated to
yield betaine (N,N,N-trimethylglycine) by the action of EC 2.1.1.157.
- Differs from EC 2.1.1.20, as it can further methylate the product of
the first reaction.
- Acetate, dimethylglycine and S-adenosyl-L-homocysteine can inhibit
the reaction.
|
| Cross-references |
|---|
| BRENDA | 2.1.1.156 |
| PUMA2 | 2.1.1.156 |
| PRIAM enzyme-specific profiles | 2.1.1.156 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.156 |
| IUBMB Enzyme Nomenclature | 2.1.1.156 |
| IntEnz | 2.1.1.156 |
| MEDLINE | Find literature relating to 2.1.1.156 |
| MetaCyc | 2.1.1.156 |
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