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NiceZyme View of ENZYME: EC 2.1.1.125

Accepted Name
Histone-arginine N-methyltransferase.
Alternative Name(s)
Histone protein methylase.
Protein methylase I.
Protein-arginine N-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + arginine-[histone] <=> S-adenosyl-L-homocysteine + N(omega)-methyl-arginine-[histone]
Comment(s)
  • Forms the N(omega)-monomethyl- and N(omega),N(omega')-dimethyl, but not the N(omega),N(omega)-dimethyl-arginine derivatives.
  • The name protein methylase I is misleading since it has been used for a number of enzymes with different specificities.
  • Formerly EC 2.1.1.23.
Cross-references
BRENDA2.1.1.125
EC2PDB2.1.1.125
PRIAM enzyme-specific profiles2.1.1.125
KEGG Ligand Database for Enzyme Nomenclature2.1.1.125
IUBMB Enzyme Nomenclature2.1.1.125
IntEnz2.1.1.125
MEDLINEFind literature relating to 2.1.1.125
MetaCyc2.1.1.125
UniProtKB/Swiss-Prot
Q8GWT4, ANM5_ARATH;  A7YW45, ANM5_BOVIN;  P46580, ANM5_CAEEL;  
Q54KI3, ANM5_DICDI;  O14744, ANM5_HUMAN;  Q4R5M3, ANM5_MACFA;  
Q8CIG8, ANM5_MOUSE;  A2X0Q3, ANM5_ORYSI;  Q6YXZ7, ANM5_ORYSJ;  
Q5R698, ANM5_PONAB;  Q5E9L5, ANM6_BOVIN;  Q6NWG4, ANM6_DANRE;  
Q96LA8, ANM6_HUMAN;  Q6NZB1, ANM6_MOUSE;  Q68EZ3, ANM6_XENLA;  
B0JYW5, ANM6_XENTR;  A6QQV6, ANM7_BOVIN;  Q5ZIB9, ANM7_CHICK;  
Q99MI9, ANM7_CRILO;  A2AV36, ANM7_DANRE;  Q9NVM4, ANM7_HUMAN;  
Q922X9, ANM7_MOUSE;  Q5U4E8, ANM7_RAT;  Q6PCI6, ANM7_XENLA;  
Q7Q2B7, CARM1_ANOGA;  B0W3L6, CARM1_CULQU;  Q6DC04, CARM1_DANRE;  
B3M1E1, CARM1_DROAN;  B3P4N5, CARM1_DROER;  B4JXV2, CARM1_DROGR;  
Q9VH48, CARM1_DROME;  B4KA23, CARM1_DROMO;  B4GZ20, CARM1_DROPE;  
Q29B63, CARM1_DROPS;  B4HJC0, CARM1_DROSE;  B4QVW6, CARM1_DROSI;  
B4LVS8, CARM1_DROVI;  B4NKI9, CARM1_DROWI;  B4PVH6, CARM1_DROYA;  
Q86X55, CARM1_HUMAN;  Q9WVG6, CARM1_MOUSE;  A2YPT7, CARM1_ORYSI;  
Q7XI75, CARM1_ORYSJ;  Q4AE70, CARM1_RAT;  Q5XK84, CARM1_XENLA;  
Q84W92, CARMA_ARATH;  A3KPF2, CARMB_ARATH;  P38274, HSL7_YEAST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-