| Official Name |
|---|
| CoB--CoM heterodisulfide reductase.
|
| Alternative Name(s) |
|---|
| Heterodisulfide reductase. |
| Soluble heterodisulfide reductase. |
| Reaction catalysed |
|---|
| Coenzyme B + coenzyme M + methanophenazine <=> N-(7-((2-sulfoethyl)dithio)heptanoyl)-O(3)-phospho-L-threonine + dihydromethanophenazine |
| Cofactor(s) |
|---|
| Heme; Iron-sulfur.
|
| Comment(s) |
|---|
- Found in methanogenic archaea, particularly Methanosarcina species,
and regenerates coenzyme M and coenzyme B after the action of
EC 2.8.4.1.
- Highly specific for both coenzyme M and coenzyme B.
- Reacts with various phenazine derivatives, including
2-hydroxyphenazine and 2-bromophenazine.
|
| Cross-references |
|---|
| BRENDA | 1.8.98.1 |
| PUMA2 | 1.8.98.1 |
| PRIAM enzyme-specific profiles | 1.8.98.1 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.8.98.1 |
| IUBMB Enzyme Nomenclature | 1.8.98.1 |
| IntEnz | 1.8.98.1 |
| MEDLINE | Find literature relating to 1.8.98.1 |
| MetaCyc | 1.8.98.1 |
| UniProtKB/Swiss-Prot |
| Q8TYP4, HDRA1_METKA; | P96801, HDRA2_METKA; | Q8TM02, HDRA_METAC; |
| P60200, HDRA_METJA; | Q8Q0T0, HDRA_METMA; | Q6LWL2, HDRA_METMP; |
| O27434, HDRA_METTH; | Q50756, HDRA_METTM; | Q58153, HDRB1_METJA; |
| Q58273, HDRB2_METJA; | Q8TIB8, HDRB_METAC; | Q8TXT8, HDRB_METKA; |
| Q8PY83, HDRB_METMA; | O27907, HDRB_METTH; | Q50755, HDRB_METTM; |
| Q58154, HDRC1_METJA; | Q58274, HDRC2_METJA; | Q8TIB9, HDRC_METAC; |
| Q8TXT7, HDRC_METKA; | Q8PY84, HDRC_METMA; | O27906, HDRC_METTH; |
| Q50754, HDRC_METTM; | Q8TSV7, HDRD_METAC; | P96797, HDRD_METBF; |
| Q8PVW3, HDRD_METMA; | Q8TSV8, HDRE_METAC; | P96796, HDRE_METBF; |
| Q8PVW4, HDRE_METMA; |
|
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