ID   1.8.4.12
DE   Peptide-methionine (R)-S-oxide reductase.
AN   Methionine S-oxide reductase.
AN   Methionine S-oxide reductase (R-form oxidizing).
AN   Methionine sulfoxide reductase.
AN   Methionine sulfoxide reductase B.
AN   Selenoprotein R.
CA   Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-
CA   methionine (R)-S-oxide + thioredoxin.
CF   Selenium; Zinc.
CC   -!- The reaction occurs in the reverse direction to that shown above.
CC   -!- Exhibits high specificity for reduction of the R-form of methionine
CC       S-oxide, with higher activity being observed with L-methionine
CC       S-oxide than with D-methionine S-oxide.
CC   -!- While both free and protein-bound methionine (R)-S-oxide act as
CC       substrates, the activity with the peptide-bound form is far greater.
CC   -!- Plays a role in preventing oxidative-stress damage caused by reactive
CC       oxygen species by reducing the oxidized form of methionine back to
CC       methionine and thereby reactivating peptides that had been damaged.
CC   -!- The reaction proceeds via a sulfenic-acid intermediate.
CC   -!- For MsrB2 and MsrB3, thioredoxin is a poor reducing agent but
CC       thionein works well.
DR   P0A3Q9, MSAB1_STRPN;  P0A3R0, MSAB1_STRR6;  P65443, MSAB2_STRPN;
DR   P65444, MSAB2_STRR6;  Q9AL99, MSRAB_ACTAC;  Q93KF3, MSRAB_CAMFE;
DR   P45213, MSRAB_HAEIN;  Q9ZMK8, MSRAB_HELPJ;  O25011, MSRAB_HELPY;
DR   P14930, MSRAB_NEIGO;  Q9JWM8, MSRAB_NEIMA;  Q9K1N8, MSRAB_NEIMB;
DR   Q9LAM9, MSRAB_STRGC;  Q99YT1, MSRAB_STRP1;  Q938P0, MSRAB_STRP3;
DR   Q5XAX5, MSRAB_STRP6;  Q8P046, MSRAB_STRP8;  O83641, MSRAB_TREPA;
DR   Q9KLX6, MSRAB_VIBCH;  Q92RA4, MSRB1_RHIME;  Q92Y46, MSRB2_RHIME;
DR   Q6FAL8, MSRB_ACIAD ;  Q8UGX7, MSRB_AGRT5 ;  Q0A706, MSRB_ALHEH ;
DR   A7Z5S1, MSRB_BACA2 ;  Q9KCX2, MSRB_BACHD ;  Q65ID2, MSRB_BACLD ;
DR   A8FEA3, MSRB_BACP2 ;  Q5WH73, MSRB_BACSK ;  P54155, MSRB_BACSU ;
DR   Q89EM9, MSRB_BRAJA ;  P65447, MSRB_BRUME ;  P65448, MSRB_BRUSU ;
DR   Q3JRF0, MSRB_BURP1 ;  Q9A6B1, MSRB_CAUCR ;  Q97IU0, MSRB_CLOAB ;
DR   Q9ZNJ9, MSRB_CLOHI ;  Q0TPZ6, MSRB_CLOP1 ;  Q8XJZ6, MSRB_CLOPE ;
DR   Q0SSL4, MSRB_CLOPS ;  Q47EU6, MSRB_DECAR ;  Q9RUK6, MSRB_DEIRA ;
DR   Q72EK2, MSRB_DESVH ;  A7ZMP8, MSRB_ECO24 ;  P0A748, MSRB_ECO57 ;
DR   A8A0X0, MSRB_ECOHS ;  Q0TH50, MSRB_ECOL5 ;  P0A747, MSRB_ECOL6 ;
DR   B1IPF3, MSRB_ECOLC ;  P0A746, MSRB_ECOLI ;  Q9XB39, MSRB_ENTFA ;
DR   Q6D4P7, MSRB_ERWCT ;  Q2SJP9, MSRB_HAHCH ;  A6T7R0, MSRB_KLEP7 ;
DR   Q9CJ17, MSRB_LACLA ;  A2RHS0, MSRB_LACLM ;  Q032Q9, MSRB_LACLS ;
DR   Q88W33, MSRB_LACPL ;  Q1WVT3, MSRB_LACS1 ;  Q72NN2, MSRB_LEPIC ;
DR   Q8F7W8, MSRB_LEPIN ;  Q92AE9, MSRB_LISIN ;  Q71YF7, MSRB_LISMF ;
DR   Q8Y641, MSRB_LISMO ;  A0AJW4, MSRB_LISW6 ;  Q46EH1, MSRB_METBF ;
DR   Q8PWF5, MSRB_METMA ;  A2SGN7, MSRB_METPP ;  O26807, MSRB_METTH ;
DR   P47686, MSRB_MYCGE ;  P75129, MSRB_MYCPN ;  Q9CMB1, MSRB_PASMU ;
DR   Q7N400, MSRB_PHOLL ;  Q48FR2, MSRB_PSE14 ;  A6V3R3, MSRB_PSEA7 ;
DR   Q02NZ0, MSRB_PSEAB ;  Q9I016, MSRB_PSEAE ;  Q1ID16, MSRB_PSEE4 ;
DR   Q4K8U5, MSRB_PSEF5 ;  A4XVB1, MSRB_PSEMY ;  A5W756, MSRB_PSEP1 ;
DR   Q3K935, MSRB_PSEPF ;  B0KUQ0, MSRB_PSEPG ;  Q88LQ6, MSRB_PSEPK ;
DR   Q885Q1, MSRB_PSESM ;  Q4ZQC6, MSRB_PSEU2 ;  Q8XYL1, MSRB_RALSO ;
DR   A9MFH4, MSRB_SALAR ;  A9N292, MSRB_SALPB ;  P65450, MSRB_SALTI ;
DR   P65449, MSRB_SALTY ;  A8GFD8, MSRB_SERP5 ;  Q321R4, MSRB_SHIBS ;
DR   Q32GC7, MSRB_SHIDS ;  Q0T4Y5, MSRB_SHIF8 ;  Q83L66, MSRB_SHIFL ;
DR   Q3Z2B6, MSRB_SHISS ;  A7X2A9, MSRB_STAA1 ;  A6U1P3, MSRB_STAA2 ;
DR   Q2FH15, MSRB_STAA3 ;  P0A088, MSRB_STAA8 ;  A5ISV4, MSRB_STAA9 ;
DR   Q2YY44, MSRB_STAAB ;  A6QGX4, MSRB_STAAE ;  P65451, MSRB_STAAM ;
DR   P99065, MSRB_STAAN ;  Q6GGY4, MSRB_STAAR ;  Q6G9D8, MSRB_STAAS ;
DR   A8Z402, MSRB_STAAT ;  P0A087, MSRB_STAAW ;  Q5HPB4, MSRB_STAEQ ;
DR   Q8CSK6, MSRB_STAES ;  Q4L6D3, MSRB_STAHJ ;  Q49XN4, MSRB_STAS1 ;
DR   Q3K1F5, MSRB_STRA1 ;  Q8E5Q9, MSRB_STRA3 ;  Q8E026, MSRB_STRA5 ;
DR   Q99ZV6, MSRB_STRP1 ;  Q8K7M6, MSRB_STRP3 ;  Q5XCD0, MSRB_STRP6 ;
DR   Q8P172, MSRB_STRP8 ;  Q8DJK9, MSRB_SYNEL ;  A5GQT3, MSRB_SYNR3 ;
DR   A5F6R2, MSRB_VIBC3 ;  Q9KQK0, MSRB_VIBCH ;  Q87MS5, MSRB_VIBPA ;
DR   Q8D849, MSRB_VIBVU ;  Q7MMC4, MSRB_VIBVY ;  Q9PF29, MSRB_XYLFA ;
DR   Q87AJ9, MSRB_XYLFT ;  A1JQG8, MSRB_YERE8 ;  A7FI81, MSRB_YERP3 ;
DR   Q1C7U0, MSRB_YERPA ;  Q8ZEK7, MSRB_YERPE ;  Q1CJ76, MSRB_YERPN ;
DR   A4TJB4, MSRB_YERPP ;  Q66AP6, MSRB_YERPS ;
//