ID 1.8.1.12 DE Trypanothione-disulfide reductase. AN N(1),N(8)-bis(glutathionyl)spermidine reductase. AN NADPH:trypanothione oxidoreductase. AN Trypanothione reductase. CA Trypanothione + NADP(+) = trypanothione disulfide + NADPH. CF FAD. CC -!- Trypanothione disulfide is the oxidized form of CC N(1),N(8)-bis(glutathionyl)-spermidine from the insect-parasitic CC trypanosomatid Crithidia fasciculata. CC -!- The activity is dependent on a redox-active cystine at the active CC center (cf. EC 1.8.1.7). CC -!- Formerly EC 1.6.4.8. PR PROSITE; PDOC00073; DR P39040, TYTR_CRIFA ; P39050, TYTR_LEIDO ; P39051, TYTR_TRYBB ; DR P13110, TYTR_TRYCO ; P28593, TYTR_TRYCR ; //