ID   1.6.3.1
DE   NAD(P)H oxidase.
AN   Dual oxidase.
AN   ThOX.
AN   THOX2.
AN   Thyroid NADPH oxidase.
AN   Thyroid oxidase.
AN   Thyroid oxidase 2.
CA   NAD(P)H + O(2) = NAD(P)(+) + H(2)O(2).
CF   Calcium; FAD; Heme.
CC   -!- When calcium is present, this transmembrane glycoprotein generates
CC       H(2)O(2) by transfering electrons from intracellular NAD(P)H to
CC       extracellular molecular oxygen.
CC   -!- The electron bridge within the enzyme contains one molecule of FAD
CC       and probably two heme groups.
CC   -!- This flavoprotein is expressed at the apical membrane of thyrocytes,
CC       and provides H(2)O(2) for the thyroid peroxidase-catalyzed
CC       biosynthesis of thyroid hormones.
PR   PROSITE; PDOC00394;
DR   O61213, DUOX1_CAEEL;  Q9MZF4, DUOX1_CANFA;  Q9NRD9, DUOX1_HUMAN;
DR   Q8HZK3, DUOX1_PIG  ;  Q8CIY2, DUOX1_RAT  ;  Q9NRD8, DUOX2_HUMAN;
DR   Q8HZK2, DUOX2_PIG  ;  Q9ES45, DUOX2_RAT  ;  Q9VQH2, DUOX_DROME ;
//