ID   1.5.1.12
DE   1-pyrroline-5-carboxylate dehydrogenase.
CA   (S)-1-pyrroline-5-carboxylate + NAD(P)(+) + 2 H(2)O = L-glutamate +
CA   NAD(P)H.
CC   -!- Oxidizes a number of 1-pyrrolines, e.g. 3-hydroxy-1-pyrroline-5-
CC       carboxylate is converted into 4-hydroxyglutamate and (R)-1-pyrroline-
CC       5-carboxylate is converted into D-glutamate.
CC   -!- While NAD(+) appears to be the better electron acceptor, NADP(+) can
CC       also act, but more slowly.
CC   -!- In many organisms, ranging from bacteria to mammals, proline is
CC       oxidized to glutamate in a two-step process involving this enzyme and
CC       EC 1.5.99.8.
CC   -!- In many bacterial species, both activities are carried out by a
CC       single bifunctional enzyme.
PR   PROSITE; PDOC00068;
DR   Q8VZC3, AL121_ARATH;  A7YWE4, AL4A1_BOVIN;  Q7SY23, AL4A1_DANRE;
DR   Q54RA2, AL4A1_DICDI;  P30038, AL4A1_HUMAN;  Q8CHT0, AL4A1_MOUSE;
DR   P0C2X9, AL4A1_RAT  ;  P78568, PUT2_AGABI ;  Q9P8I0, PUT2_EMENI ;
DR   O74766, PUT2_SCHPO ;  P07275, PUT2_YEAST ;  P09546, PUTA_ECOLI ;
DR   O52485, PUTA_KLEAE ;  P23725, PUTA_KLEPN ;  P95629, PUTA_RHIME ;
DR   P10503, PUTA_SALTY ;  Q9K9B2, ROCA1_BACHD;  Q9K5Z5, ROCA2_BACHD;
DR   P94391, ROCA2_BACSU;  A0R909, ROCA_BACAH ;  Q81ZF8, ROCA_BACAN ;
DR   P62028, ROCA_BACC1 ;  A7GKJ4, ROCA_BACCN ;  Q81IP0, ROCA_BACCR ;
DR   Q63GS0, ROCA_BACCZ ;  Q6HP91, ROCA_BACHK ;  Q65NN2, ROCA_BACLD ;
DR   A8F9T1, ROCA_BACP2 ;  P39634, ROCA_BACSU ;  Q5L3K8, ROCA_GEOKA ;
DR   A4IJP9, ROCA_GEOTN ;  Q8ERF4, ROCA_OCEIH ;  A7X6R7, ROCA_STAA1 ;
DR   A6U4T5, ROCA_STAA2 ;  Q2FDV3, ROCA_STAA3 ;  Q2FV67, ROCA_STAA8 ;
DR   A5IVY0, ROCA_STAA9 ;  Q2YWA6, ROCA_STAAB ;  Q5HCZ6, ROCA_STAAC ;
DR   A6QK44, ROCA_STAAE ;  P63939, ROCA_STAAM ;  P99076, ROCA_STAAN ;
DR   Q6GDP4, ROCA_STAAR ;  Q6G6C0, ROCA_STAAS ;  A8Z3F5, ROCA_STAAT ;
DR   Q8NUR2, ROCA_STAAW ;  Q5HL59, ROCA_STAEQ ;  Q8CN04, ROCA_STAES ;
DR   Q4L966, ROCA_STAHJ ;  Q4A0E7, ROCA_STAS1 ;
//