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NiceZyme View of ENZYME: EC 1.2.1.70

Official Name
Glutamyl-tRNA reductase.
Reaction catalysed
L-glutamate 1-semialdehyde + NADP(+) + tRNA(Glu) <=> L-glutamyl-tRNA(Glu) + NADPH
Comment(s)
  • Forms part of the pathway for the biosynthesis of 5-aminolevulinate from glutamate, known as the C5 pathway, which is used in most eubacteria, and in all archaebacteria, algae and plants.
  • However, in the alpha-proteobacteria EC 2.3.1.37 is used in an alternative route to produce the product 5-aminolevulinate from succinyl-CoA and glycine.
  • This route is found in the mitochondria of fungi and animals, organelles that are considered to be derived from an endosymbiotic alpha-proteobacterium.
  • Although higher plants do not possess EC 2.3.1.37, the protistan Euglena gracilis possesses both the C5 pathway and EC 2.3.1.37.
Cross-references
PROSITEPDOC00608
BRENDA1.2.1.70
PUMA21.2.1.70
PRIAM enzyme-specific profiles1.2.1.70
KEGG Ligand Database for Enzyme Nomenclature1.2.1.70
IUBMB Enzyme Nomenclature1.2.1.70
IntEnz1.2.1.70
MEDLINEFind literature relating to 1.2.1.70
MetaCyc1.2.1.70
UniProtKB/Swiss-Prot
Q1ITN7, HEM11_ACIBL;  Q2IJD4, HEM11_ANADE;  A7HA35, HEM11_ANADF;  
P42804, HEM11_ARATH;  A9KP81, HEM11_CLOPH;  P93111, HEM11_CUCSA;  
A5FLE3, HEM11_FLAJO;  Q42843, HEM11_HORVU;  A1SE01, HEM11_NOCSJ;  
A4WJE1, HEM11_PYRAR;  A3MW83, HEM11_PYRCJ;  Q1INI5, HEM12_ACIBL;  
Q2IKT3, HEM12_ANADE;  A7HBF2, HEM12_ANADF;  P49294, HEM12_ARATH;  
A9KSC2, HEM12_CLOPH;  P49295, HEM12_CUCSA;  A5FDF9, HEM12_FLAJO;  
Q96563, HEM12_HORVU;  A1SI37, HEM12_NOCSJ;  A4WN38, HEM12_PYRAR;  
A3MXT2, HEM12_PYRCJ;  O65796, HEM13_HORVU;  B0BZF9, HEM1_ACAM1;  
A1TTC3, HEM1_ACIAC;  Q6F8J3, HEM1_ACIAD;  A3M2X7, HEM1_ACIBT;  
A0LRF2, HEM1_ACIC1;  A1W4B9, HEM1_ACISJ;  A3MZC2, HEM1_ACTP2;  
A6VND5, HEM1_ACTSZ;  A0KMZ9, HEM1_AERHH;  Q9Y9J2, HEM1_AERPE;  
A4SK63, HEM1_AERS4;  Q0VS78, HEM1_ALCBS;  Q0AC03, HEM1_ALHEH;  
A6TJD3, HEM1_ALKMQ;  A8MGE1, HEM1_ALKOO;  O08393, HEM1_ANASP;  
Q3M6T2, HEM1_ANAVT;  O67314, HEM1_AQUAE;  A8ERT8, HEM1_ARCB4;  
O28304, HEM1_ARCFU;  A1R8A6, HEM1_ARTAT;  A0JYN2, HEM1_ARTS2;  
A1K442, HEM1_AZOSB;  Q5P7G6, HEM1_AZOSE;  A7Z7A7, HEM1_BACA2;  
A0RJ83, HEM1_BACAH;  Q81LC5, HEM1_BACAN;  Q72ZW0, HEM1_BACC1;  
A7GTE7, HEM1_BACCN;  Q817Q8, HEM1_BACCR;  Q633X8, HEM1_BACCZ;  
Q9K8F8, HEM1_BACHD;  Q6HD60, HEM1_BACHK;  Q65GJ9, HEM1_BACLD;  
Q8GCB0, HEM1_BACME;  A8FFV4, HEM1_BACP2;  Q5WEP3, HEM1_BACSK;  
P16618, HEM1_BACSU;  Q2KZZ5, HEM1_BORA1;  Q7WQF0, HEM1_BORBR;  
Q7WCE4, HEM1_BORPA;  Q7VRY3, HEM1_BORPE;  Q1BSB3, HEM1_BURCA;  
A0K438, HEM1_BURCH;  Q0BIP9, HEM1_BURCM;  A3MFT3, HEM1_BURM7;  
A2RYL1, HEM1_BURM9;  Q62DF2, HEM1_BURMA;  A1UWC8, HEM1_BURMS;  
A3NZS3, HEM1_BURP0;  Q3JN88, HEM1_BURP1;  A3NE23, HEM1_BURP6;  
Q63QF1, HEM1_BURPS;  Q39K17, HEM1_BURS3;  Q2SUG3, HEM1_BURTA;  
A4JB51, HEM1_BURVG;  Q13TU3, HEM1_BURXL;  A8MAH6, HEM1_CALMQ;  
A4XK04, HEM1_CALS8;  A7ZD34, HEM1_CAMC1;  A7GYU7, HEM1_CAMC5;  
A0RNT0, HEM1_CAMFF;  A7I1R7, HEM1_CAMHC;  A8FKW5, HEM1_CAMJ8;  
A7H4K0, HEM1_CAMJD;  Q9PHX2, HEM1_CAMJE;  A1VYQ1, HEM1_CAMJJ;  
Q5HVM4, HEM1_CAMJR;  Q3ACT4, HEM1_CARHZ;  A0RXF8, HEM1_CENSY;  
A9WIS2, HEM1_CHLAA;  Q3AQF4, HEM1_CHLCH;  Q824W1, HEM1_CHLCV;  
Q252N9, HEM1_CHLFF;  Q9PLR2, HEM1_CHLMU;  A1BHD5, HEM1_CHLPD;  
Q9Z7J1, HEM1_CHLPN;  Q3KL32, HEM1_CHLTA;  Q93ST4, HEM1_CHLTE;  
O84669, HEM1_CHLTR;  P28462, HEM1_CHLVI;  Q1QXC7, HEM1_CHRSD;  
Q7P1Y3, HEM1_CHRVO;  A8AG01, HEM1_CITK8;  A5CNH4, HEM1_CLAM3;  
B0RBM5, HEM1_CLAMS;  Q97MU6, HEM1_CLOAB;  A6LSY3, HEM1_CLOB8;  
Q59292, HEM1_CLOJO;  A5N5Y0, HEM1_CLOK5;  A0Q2B3, HEM1_CLONN;  
Q0TQG2, HEM1_CLOP1;  P0C2E3, HEM1_CLOPE;  Q0ST14, HEM1_CLOPS;  
Q897K9, HEM1_CLOTE;  A3DIE8, HEM1_CLOTH;  Q47Y92, HEM1_COLP3;  
Q6NJK1, HEM1_CORDI;  Q8FSF8, HEM1_COREF;  A4QB58, HEM1_CORGB;  
P0C543, HEM1_CORGL;  Q4JSX4, HEM1_CORJK;  A9KGY4, HEM1_COXBN;  
A9N9K1, HEM1_COXBR;  P47846, HEM1_COXBU;  P48077, HEM1_CYAPA;  
Q11Y93, HEM1_CYTH3;  Q479R3, HEM1_DECAR;  Q1IWG2, HEM1_DEIGD;  
Q9RRE5, HEM1_DEIRA;  Q30ZS4, HEM1_DESDG;  Q24VC7, HEM1_DESHY;  
Q6AIM2, HEM1_DESPS;  A4J6H8, HEM1_DESRM;  Q72C23, HEM1_DESVH;  
Q9KW52, HEM1_DESVM;  A1VDW9, HEM1_DESVV;  A5EWV4, HEM1_DICNV;  
A7ZKY4, HEM1_ECO24;  P0A6X2, HEM1_ECO57;  A7ZZE6, HEM1_ECOHS;  
A1AAD7, HEM1_ECOK1;  Q0TIG0, HEM1_ECOL5;  Q8FI03, HEM1_ECOL6;  
B1IU83, HEM1_ECOLC;  P0A6X1, HEM1_ECOLI;  Q1RCM8, HEM1_ECOUT;  
A4WBC7, HEM1_ENT38;  A7MKC0, HEM1_ENTS8;  Q6D552, HEM1_ERWCT;  
A6GVP1, HEM1_FLAPJ;  Q0RS17, HEM1_FRAAA;  B0TX36, HEM1_FRAP2;  
Q2JFS1, HEM1_FRASC;  Q14JR2, HEM1_FRAT1;  A7NE97, HEM1_FRATF;  
Q2A1P9, HEM1_FRATH;  A0Q845, HEM1_FRATN;  Q0BKE7, HEM1_FRATO;  
Q5NIA9, HEM1_FRATT;  A4IWC0, HEM1_FRATW;  Q8R687, HEM1_FUSNN;  
Q5KWK4, HEM1_GEOKA;  Q39QM8, HEM1_GEOMG;  Q747I2, HEM1_GEOSL;  
A4IRG7, HEM1_GEOTN;  A5GCW3, HEM1_GEOUR;  Q7NLA8, HEM1_GLOVI;  
A0M6C1, HEM1_GRAFK;  Q0I3Q6, HEM1_HAES1;  Q2SL96, HEM1_HAHCH;  
A1WVQ7, HEM1_HALHL;  Q5V1I8, HEM1_HALMA;  Q9HP72, HEM1_HALSA;  
Q18F28, HEM1_HALWD;  Q17W63, HEM1_HELAH;  Q7VFF1, HEM1_HELHP;  
Q9ZGG6, HEM1_HELMO;  Q1CUR3, HEM1_HELPH;  Q9ZMJ5, HEM1_HELPJ;  
P56125, HEM1_HELPY;  A4G1N3, HEM1_HERAR;  A2BJB7, HEM1_HYPBU;  
Q5QV08, HEM1_IDILO;  A8A9U3, HEM1_IGNH4;  A6SUF7, HEM1_JANMA;  
A6W5L7, HEM1_KINRD;  A6TAP0, HEM1_KLEP7;  A5VM68, HEM1_LACRF;  
Q1MRJ8, HEM1_LAWIP;  Q5X2V4, HEM1_LEGPA;  A5IED6, HEM1_LEGPC;  
Q5ZT30, HEM1_LEGPH;  Q5WUB2, HEM1_LEGPL;  Q6AHF6, HEM1_LEIXX;  
Q92BF7, HEM1_LISIN;  Q71ZB1, HEM1_LISMF;  Q8Y6X4, HEM1_LISMO;  
A0AJ06, HEM1_LISW6;  A0LDT6, HEM1_MAGSM;  Q65SX9, HEM1_MANSM;  
A1U368, HEM1_MARAV;  A6W1C3, HEM1_MARMS;  A6UT22, HEM1_META3;  
Q8TT60, HEM1_METAC;  A7I7P5, HEM1_METB6;  Q46CH3, HEM1_METBF;  
Q12WM5, HEM1_METBU;  Q60A20, HEM1_METCA;  Q1GYE9, HEM1_METFK;  
Q2FTL0, HEM1_METHJ;  Q60172, HEM1_METJA;  Q9UXR8, HEM1_METKA;  
A2SQU1, HEM1_METLZ;  A4G0A1, HEM1_METM5;  A6VI77, HEM1_METM7;  
Q8PW60, HEM1_METMA;  A3CU63, HEM1_METMJ;  Q6M130, HEM1_METMP;  
A2SD47, HEM1_METPP;  A5ULU4, HEM1_METS3;  A4YD89, HEM1_METS5;  
Q2NEH4, HEM1_METST;  O27093, HEM1_METTH;  P42809, HEM1_METTM;  
A0B577, HEM1_METTP;  A6UR78, HEM1_METVS;  Q2RJ25, HEM1_MOOTA;  
A0QLI1, HEM1_MYCA1;  P64329, HEM1_MYCBO;  A1KFY5, HEM1_MYCBP;  
A4T341, HEM1_MYCGI;  P46724, HEM1_MYCLE;  Q73SS1, HEM1_MYCPA;  
A0QR17, HEM1_MYCS2;  A3PUA3, HEM1_MYCSJ;  A1UAP7, HEM1_MYCSK;  
Q1BE87, HEM1_MYCSS;  A5TZN9, HEM1_MYCTA;  P64328, HEM1_MYCTU;  
A0PW28, HEM1_MYCUA;  A1T3D2, HEM1_MYCVP;  Q1D8Z9, HEM1_MYXXD;  
Q3ING1, HEM1_NATPD;  Q9ZHD6, HEM1_NEIG1;  A9M2B8, HEM1_NEIM0;  
P0A0T7, HEM1_NEIMA;  P56994, HEM1_NEIMB;  P0A0T8, HEM1_NEIMC;  
A1KSI5, HEM1_NEIMF;  Q0AHU2, HEM1_NITEC;  Q82TH3, HEM1_NITEU;  
Q2Y5P2, HEM1_NITMU;  Q3JDR3, HEM1_NITOC;  A6Q3S5, HEM1_NITSB;  
Q5YP69, HEM1_NOCFA;  Q8EPM7, HEM1_OCEIH;  A2Z928, HEM1_ORYSI;  
P0C587, HEM1_ORYSJ;  O69108, HEM1_PAEMA;  Q6MEC8, HEM1_PARUW;  
P95525, HEM1_PASMU;  Q3A008, HEM1_PELCD;  Q3B2Z6, HEM1_PELLD;  
A1AUE9, HEM1_PELPD;  A5D3L4, HEM1_PELTS;  Q7N587, HEM1_PHOLL;  
Q6LNB3, HEM1_PHOPR;  Q6L0J9, HEM1_PICTO;  A1VKB7, HEM1_POLNA;  
Q12F85, HEM1_POLSJ;  A4SV44, HEM1_POLSQ;  Q6AB02, HEM1_PROAC;  
A3PCH6, HEM1_PROM0;  A2C1K4, HEM1_PROM1;  A8G4E6, HEM1_PROM2;  
A2CAB8, HEM1_PROM3;  A2BW63, HEM1_PROM5;  Q31BA9, HEM1_PROM9;  
Q7VCA1, HEM1_PROMA;  Q7V809, HEM1_PROMM;  Q7V1T7, HEM1_PROMP;  
A2BQQ3, HEM1_PROMS;  Q46LG2, HEM1_PROMT;  A4SFJ7, HEM1_PROVI;  
Q48MV5, HEM1_PSE14;  Q15SQ8, HEM1_PSEA6;  A6VC62, HEM1_PSEA7;  
Q02G08, HEM1_PSEAB;  P42807, HEM1_PSEAE;  Q1IEX2, HEM1_PSEE4;  
Q4K694, HEM1_PSEF5;  Q3IK96, HEM1_PSEHT;  A4XR60, HEM1_PSEMY;  
A5VYG4, HEM1_PSEP1;  Q3K6W8, HEM1_PSEPF;  B0KNE3, HEM1_PSEPG;  
Q88PW6, HEM1_PSEPK;  Q888C2, HEM1_PSESM;  Q4ZXW8, HEM1_PSEU2;  
A4VPC0, HEM1_PSEU5;  Q4FVA9, HEM1_PSYA2;  Q1QED0, HEM1_PSYCK;  
A1SV88, HEM1_PSYIN;  A5WC75, HEM1_PSYWF;  Q8ZYV6, HEM1_PYRAE;  
A1RQP7, HEM1_PYRIL;  Q0K6G3, HEM1_RALEH;  Q46WT0, HEM1_RALEJ;  
Q1LIF4, HEM1_RALME;  Q8XVD1, HEM1_RALSO;  A9WPH1, HEM1_RENSM;  
Q7UKZ2, HEM1_RHOBA;  Q21YY8, HEM1_RHOFD;  Q2RWE2, HEM1_RHORT;  
Q0SF26, HEM1_RHOSR;  A7NKU4, HEM1_ROSCS;  A5UU33, HEM1_ROSS1;  
Q1AUK2, HEM1_RUBXD;  A1AX01, HEM1_RUTMC;  Q21FM2, HEM1_SACD2;  
A4FPY4, HEM1_SACEN;  A8LZI9, HEM1_SALAI;  A9MPA0, HEM1_SALAR;  
Q57NN4, HEM1_SALCH;  Q5PCR0, HEM1_SALPA;  A9MW03, HEM1_SALPB;  
Q2S2A5, HEM1_SALRD;  P0A1Q7, HEM1_SALTI;  A4X1U1, HEM1_SALTO;  
P0A1Q6, HEM1_SALTY;  A8GDA2, HEM1_SERP5;  A1S8R3, HEM1_SHEAM;  
A3D0G0, HEM1_SHEB5;  A6WSF1, HEM1_SHEB8;  A9L2D5, HEM1_SHEB9;  
Q12QR9, HEM1_SHEDO;  Q087I5, HEM1_SHEFN;  B0TR28, HEM1_SHEHH;  
A3QH31, HEM1_SHELP;  Q8EAR2, HEM1_SHEON;  A8H7A6, HEM1_SHEPA;  
A4Y3J7, HEM1_SHEPC;  A0KT87, HEM1_SHESA;  A8FYZ1, HEM1_SHESH;  
Q0HFC7, HEM1_SHESM;  Q0HYK9, HEM1_SHESR;  A1RNE2, HEM1_SHESW;  
Q31ZQ3, HEM1_SHIBS;  Q32GZ7, HEM1_SHIDS;  Q0T5I5, HEM1_SHIF8;  
Q83RP1, HEM1_SHIFL;  Q3Z0S8, HEM1_SHISS;  Q2NRS3, HEM1_SODGM;  
Q022E5, HEM1_SOLUE;  A9FDP5, HEM1_SORC5;  A7X393, HEM1_STAA1;  
A6U2E0, HEM1_STAA2;  Q2FG64, HEM1_STAA3;  Q2FXQ9, HEM1_STAA8;  
A5ITJ7, HEM1_STAA9;  Q2YTB7, HEM1_STAAB;  Q5HFA0, HEM1_STAAC;  
A6QHK6, HEM1_STAAE;  P64330, HEM1_STAAM;  P64331, HEM1_STAAN;  
Q6GG33, HEM1_STAAR;  Q6G8Q3, HEM1_STAAS;  A8Z2J3, HEM1_STAAT;  
P64332, HEM1_STAAW;  Q5HNN1, HEM1_STAEQ;  Q8CNY6, HEM1_STAES;  
Q4L711, HEM1_STAHJ;  Q49YA4, HEM1_STAS1;  Q82E77, HEM1_STRAW;  
Q9WX15, HEM1_STRCO;  A3CL77, HEM1_STRSV;  Q4JAM9, HEM1_SULAC;  
Q30S94, HEM1_SULDN;  A6Q7Y8, HEM1_SULNB;  Q980U7, HEM1_SULSO;  
Q976H4, HEM1_SULTO;  Q2LQU3, HEM1_SYNAS;  Q8DI53, HEM1_SYNEL;  
A0LIM5, HEM1_SYNFM;  Q2JWU6, HEM1_SYNJA;  Q2JJG8, HEM1_SYNJB;  
Q5N3B4, HEM1_SYNP6;  Q31QY3, HEM1_SYNP7;  A5GLB0, HEM1_SYNPW;  
Q7U769, HEM1_SYNPX;  A5GTE8, HEM1_SYNR3;  Q0I9I2, HEM1_SYNS3;  
Q3AXK4, HEM1_SYNS9;  Q3AK73, HEM1_SYNSC;  P28463, HEM1_SYNY3;  
Q9HKR0, HEM1_THEAC;  Q47LA6, HEM1_THEFY;  A6LKW9, HEM1_THEM4;  
Q72IJ0, HEM1_THET2;  Q5SI68, HEM1_THET8;  Q97B68, HEM1_THEVO;  
Q31IN7, HEM1_THICR;  Q3SG11, HEM1_THIDA;  Q117I4, HEM1_TRIEI;  
Q83H91, HEM1_TROW8;  Q83FI9, HEM1_TROWT;  Q0W5T5, HEM1_UNCMA;  
A1WI55, HEM1_VEREI;  A5CW97, HEM1_VESOH;  A5F697, HEM1_VIBC3;  
Q9KQ24, HEM1_VIBCH;  Q5E6T4, HEM1_VIBF1;  A7MY81, HEM1_VIBHB;  
Q87RN5, HEM1_VIBPA;  Q8DFF8, HEM1_VIBVU;  Q7MMY7, HEM1_VIBVY;  
Q8D2K8, HEM1_WIGBR;  Q7MBG5, HEM1_WOLSU;  Q8PNU4, HEM1_XANAC;  
Q3BX06, HEM1_XANC5;  Q4URB7, HEM1_XANC8;  B0RUA4, HEM1_XANCB;  
P42808, HEM1_XANCH;  Q8PC67, HEM1_XANCP;  Q2NZW3, HEM1_XANOM;  
Q5GWR0, HEM1_XANOR;  Q9PA72, HEM1_XYLFA;  Q87A18, HEM1_XYLFT;  
A1JRU4, HEM1_YERE8;  A7FIG2, HEM1_YERP3;  Q1C855, HEM1_YERPA;  
Q8ZEX9, HEM1_YERPE;  Q1CJK2, HEM1_YERPN;  A4TJN8, HEM1_YERPP;  
Q66AX6, HEM1_YERPS;  

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