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NiceZyme View of ENZYME: EC 1.2.1.12

Official Name
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating).
Alternative Name(s)
GAPDH.
NAD-dependent glyceraldehyde-3-phosphate dehydrogenase.
Triosephosphate dehydrogenase.
Reaction catalysed
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) <=> 3-phospho-D-glyceroyl phosphate + NADH
Comment(s)
  • Also acts very slowly on D-glyceraldehyde and some other aldehydes.
  • Thiols can replace phosphate.
Cross-references
Biochemical Pathways; map number(s)D5
PROSITEPDOC00069
BRENDA1.2.1.12
PUMA21.2.1.12
PRIAM enzyme-specific profiles1.2.1.12
KEGG Ligand Database for Enzyme Nomenclature1.2.1.12
IUBMB Enzyme Nomenclature1.2.1.12
IntEnz1.2.1.12
MEDLINEFind literature relating to 1.2.1.12
MetaCyc1.2.1.12
UniProtKB/Swiss-Prot
P32635, G3P1_AGABI;  P80506, G3P1_ANASP;  P34916, G3P1_ANAVT;  
Q4MQ58, G3P1_BACCE;  P09124, G3P1_BACSU;  P04970, G3P1_CAEEL;  
Q6FPW3, G3P1_CANGA;  P07486, G3P1_DROME;  P0A9B4, G3P1_ECO57;  
P0A9B3, G3P1_ECOL6;  P0A9B2, G3P1_ECOLI;  P24751, G3P1_ESCVU;  
P53429, G3P1_GIALA;  O16027, G3P1_GLORO;  P80534, G3P1_JACOR;  
P17819, G3P1_KLULA;  P84998, G3P1_KLUMA;  Q9C136, G3P1_RHIRA;  
P0A1P1, G3P1_SALTI;  P0A1P0, G3P1_SALTY;  P78958, G3P1_SCHPO;  
P0A9B5, G3P1_SHIFL;  Q5HHP5, G3P1_STAAC;  P0A036, G3P1_STAAM;  
P99136, G3P1_STAAN;  Q6GIL8, G3P1_STAAR;  Q6GB58, G3P1_STAAS;  
P0A038, G3P1_STAAU;  P0A037, G3P1_STAAW;  Q5HQV4, G3P1_STAEQ;  
Q8CPY5, G3P1_STAES;  P49433, G3P1_SYNY3;  P17729, G3P1_TRIKO;  
P00360, G3P1_YEAST;  P32636, G3P2_AGABI;  P58554, G3P2_ANASP;  
P34917, G3P2_ANAVT;  P83077, G3P2_BACCE;  P32809, G3P2_CAEBR;  
P17329, G3P2_CAEEL;  Q6FSM4, G3P2_CANGA;  P07487, G3P2_DROME;  
O44104, G3P2_DROPS;  O44105, G3P2_DROSU;  P80447, G3P2_JACOR;  
Q6CX23, G3P2_KLULA;  Q01077, G3P2_KLUMA;  Q96UF2, G3P2_RHIRA;  
P29272, G3P2_RHOSH;  O43026, G3P2_SCHPO;  Q5HF86, G3P2_STAAC;  
P64180, G3P2_STAAM;  P99067, G3P2_STAAN;  Q6GG19, G3P2_STAAR;  
Q6G8N9, G3P2_STAAS;  P64181, G3P2_STAAW;  Q5HNL7, G3P2_STAEQ;  
Q8CNY0, G3P2_STAES;  P17730, G3P2_TRIKO;  P00358, G3P2_YEAST;  
P58559, G3P3_ANASP;  P34918, G3P3_ANAVT;  P32810, G3P3_CAEBR;  
P17330, G3P3_CAEEL;  P58072, G3P3_ECO57;  P33898, G3P3_ECOLI;  
P84999, G3P3_KLUMA;  Q96UF1, G3P3_RHIRA;  P00359, G3P3_YEAST;  
P17331, G3P4_CAEEL;  P25861, G3PC_ANTMA;  P25858, G3PC_ARATH;  
P49644, G3PC_CHLRE;  P34920, G3PC_CHOCR;  Q42671, G3PC_CRAPL;  
P34921, G3PC_DIACA;  Q39769, G3PC_GINBI;  P54270, G3PC_GRAVE;  
P08477, G3PC_HORVU;  Q01558, G3PC_LEIME;  P26518, G3PC_MAGLI;  
P08735, G3PC_MAIZE;  P17878, G3PC_MESCR;  A2YQT7, G3PC_ORYSI;  
Q0J8A4, G3PC_ORYSJ;  P34922, G3PC_PEA;  P26519, G3PC_PETCR;  
P26520, G3PC_PETHY;  P34923, G3PC_PHYPA;  P34924, G3PC_PINSY;  
P50321, G3PC_RALEH;  P26521, G3PC_RANAC;  Q8VXQ8, G3PC_SCEVA;  
P04796, G3PC_SINAL;  Q41595, G3PC_TAXBA;  P09094, G3PC_TOBAC;  
P10097, G3PC_TRYBB;  Q09054, G3PD_MAIZE;  Q43247, G3PE_MAIZE;  
O96423, G3PG_CRIFA;  Q27890, G3PG_LEIME;  P22512, G3PG_TRYBB;  
P22513, G3PG_TRYCR;  P50322, G3PP_RALEH;  Q2KJE5, G3PT_BOVIN;  
O14556, G3PT_HUMAN;  Q4R3T1, G3PT_MACFA;  Q64467, G3PT_MOUSE;  
P26517, G3PX_HORVU;  Q9HFX1, G3P_AJECA;  P55071, G3P_AMAMU;  
O67161, G3P_AQUAE;  Q757I2, G3P_ASHGO;  Q12552, G3P_ASPNG;  
Q9HGY7, G3P_ASPOR;  P34783, G3P_ATRNU;  P15115, G3P_BACCO;  
Q59199, G3P_BACFR;  P23722, G3P_BACME;  P00362, G3P_BACST;  
Q00301, G3P_BOLED;  P46795, G3P_BORBU;  P46796, G3P_BORHE;  
P10096, G3P_BOVIN;  P48812, G3P_BRUMA;  P57384, G3P_BUCAI;  
Q07234, G3P_BUCAP;  Q89AK1, G3P_BUCBP;  Q92211, G3P_CANAL;  
Q28259, G3P_CANFA;  P70685, G3P_CAVPO;  P00356, G3P_CHICK;  
Q9PJN6, G3P_CHLMU;  Q9Z7T0, G3P_CHLPN;  Q46450, G3P_CHLTR;  
P24748, G3P_CITFR;  Q00584, G3P_CLAPU;  O52631, G3P_CLOAB;  
Q59309, G3P_CLOPA;  P29497, G3P_COCHE;  Q1DTF9, G3P_COCIM;  
Q8J1H3, G3P_COCPO;  P35143, G3P_COLGL;  O57479, G3P_COLLI;  
P54117, G3P_COLLN;  Q01651, G3P_CORGL;  Q05025, G3P_COTJA;  
P17244, G3P_CRIGR;  Q9Y796, G3P_CRYCU;  Q9Y8E9, G3P_CRYNE;  
P19089, G3P_CRYPA;  P28844, G3P_CURLU;  Q6BMK0, G3P_DEBHA;  
Q94469, G3P_DICDI;  Q01597, G3P_DROHY;  Q27652, G3P_ECHMU;  
P20445, G3P_EMENI;  P24163, G3P_ENTAE;  Q00640, G3P_ERYGR;  
P24749, G3P_ESCBL;  P24746, G3P_ESCFE;  P24750, G3P_ESCHE;  
Q9N2D5, G3P_FELCA;  Q4U3L0, G3P_GLOMM;  P44304, G3P_HAEIN;  
Q9ZKT0, G3P_HELPJ;  P55971, G3P_HELPY;  P00357, G3P_HOMAM;  
P04406, G3P_HUMAN;  P24164, G3P_KLEPN;  O32755, G3P_LACDE;  
P55070, G3P_LACDT;  P52987, G3P_LACLA;  Q9UR38, G3P_LENED;  
Q92243, G3P_LYOSH;  Q9N655, G3P_MASBA;  O57672, G3P_MELGA;  
P51640, G3P_MESAU;  P53430, G3P_MONAN;  P16858, G3P_MOUSE;  
A3FKF7, G3P_MUSPF;  P94915, G3P_MYCAV;  P64179, G3P_MYCBO;  
P47543, G3P_MYCGE;  P46713, G3P_MYCLE;  P75358, G3P_MYCPN;  
P64178, G3P_MYCTU;  P83601, G3P_NAEFO;  P54118, G3P_NEUCR;  
Q8TFJ2, G3P_OMPOL;  O42259, G3P_ONCMY;  O01360, G3P_ONCVO;  
P56649, G3P_PALVE;  Q8X1X3, G3P_PARBR;  Q01982, G3P_PHACH;  
Q9P8C0, G3P_PHANO;  O13507, G3P_PHARH;  P26988, G3P_PHYIN;  
O59841, G3P_PICAN;  Q9UVC0, G3P_PICCI;  Q92263, G3P_PICPA;  
P00355, G3P_PIG;  Q9UW96, G3P_PLESA;  P32637, G3P_PODAN;  
Q5RAB4, G3P_PONAB;  P27726, G3P_PSEAE;  P46406, G3P_RABIT;  
P52694, G3P_RALSO;  P04797, G3P_RAT;  Q8NK47, G3P_RHIMI;  
P32638, G3P_SCHCO;  P20287, G3P_SCHMA;  Q96US8, G3P_SCLSC;  
P24166, G3P_SERMA;  P24753, G3P_SEROD;  Q28554, G3P_SHEEP;  
Q8WZN0, G3P_SORMA;  Q4KYY3, G3P_SPECI;  P54226, G3P_STRAE;  
Q59800, G3P_STRAU;  Q9Z518, G3P_STRCO;  Q59906, G3P_STREQ;  
P0C0G7, G3P_STRP1;  Q8K8M9, G3P_STRP3;  Q5XDW3, G3P_STRP6;  
P68777, G3P_STRP8;  P0C0G6, G3P_STRPY;  P00361, G3P_THEAQ;  
P17721, G3P_THEMA;  O83816, G3P_TREPA;  P87197, G3P_TRIAT;  
Q5R2J2, G3P_TRISI;  P09317, G3P_USTMA;  P51009, G3P_XANFL;  
P51469, G3P_XENLA;  Q6CCU7, G3P_YARLI;  P08439, G3P_ZYGRO;  
P09316, G3P_ZYMMO;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
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