ID   1.14.16.2
DE   Tyrosine 3-monooxygenase.
AN   L-tyrosine hydroxylase.
AN   Tyrosine 3-hydroxylase.
AN   Tyrosine hydroxylase.
CA   L-tyrosine + tetrahydrobiopterin + O(2) = 3,4-dihydroxy-L-phenylalanine +
CA   4a-hydroxytetrahydrobiopterin.
CF   Iron.
CC   -!- Activated by phosphorylation, catalyzed by EC 2.7.11.27.
CC   -!- The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7-
CC       dihydrobiopterin, both spontaneously and by the action of
CC       EC 4.2.1.96.
CC   -!- The 6,7-dihydrobiopterin can be enzymically reduced back to
CC       tetrahydrobiopterin, by EC 1.5.1.34, or slowly rearranges into the
CC       more stable compound 7,8-dihydrobiopterin.
PR   PROSITE; PDOC00316;
DR   O42091, TY3H_ANGAN ;  P17289, TY3H_BOVIN ;  P90986, TY3H_CAEEL ;
DR   Q76IQ3, TY3H_CANFA ;  P18459, TY3H_DROME ;  P07101, TY3H_HUMAN ;
DR   P24529, TY3H_MOUSE ;  P11982, TY3H_PHASP ;  P04177, TY3H_RAT   ;
DR   O17446, TY3H_SCHMA ;
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