| Official Name |
|---|
| Unspecific monooxygenase.
|
| Alternative Name(s) |
|---|
| Aryl hydrocarbon hydroxylase. |
| Aryl-4-monooxygenase. |
| Cytochrome p450. |
| Flavoprotein-linked monooxygenase. |
| Microsomal monooxygenase. |
| Microsomal p450. |
| Xenobiotic monooxygenase. |
| Reaction catalysed |
|---|
| RH + reduced flavoprotein + O(2) <=> ROH + oxidized flavoprotein + H(2)O |
| Cofactor(s) |
|---|
| Heme-thiolate.
|
| Comment(s) |
|---|
- Acts on a wide range of substrates including many xenobiotics,
steroids, fatty acids, vitamins and prostaglandins.
- Reactions catalyzed include hydroxylation, epoxidation, N-oxidation,
sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination,
and reduction of azo, nitro, and N-oxide groups.
- Formerly EC 1.14.1.1, EC 1.14.14.2, EC 1.14.99.8 and EC 1.99.1.1.
|
| Cross-references |
|---|
| Biochemical Pathways; map number(s) | T6 ; U6 |
| PROSITE | PDOC00081 |
| BRENDA | 1.14.14.1 |
| PUMA2 | 1.14.14.1 |
| PRIAM enzyme-specific profiles | 1.14.14.1 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.14.1 |
| IUBMB Enzyme Nomenclature | 1.14.14.1 |
| IntEnz | 1.14.14.1 |
| MEDLINE | Find literature relating to 1.14.14.1 |
| MetaCyc | 1.14.14.1 |
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