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NiceZyme View of ENZYME: EC 1.14.13.39

Official Name
Nitric-oxide synthase.
Alternative Name(s)
Endothelium-derived relaxation factor-forming enzyme.
Endothelium-derived relaxing factor synthase.
NADPH-diaphorase.
Nitric-oxide synthetase.
NO synthase.
Reaction catalysed
L-arginine + n NADPH + m O(2) <=> citrulline + nitric oxide + n NADP(+)
Comment(s)
  • The enzyme in brain, but not that induced in lung or liver by endotoxin, requires calcium.
  • The stoichiometry is not clear, but may involve a two-electron and a one-electron oxidation step.
Cross-references
BRENDA1.14.13.39
PUMA21.14.13.39
PRIAM enzyme-specific profiles1.14.13.39
KEGG Ligand Database for Enzyme Nomenclature1.14.13.39
IUBMB Enzyme Nomenclature1.14.13.39
IntEnz1.14.13.39
MEDLINEFind literature relating to 1.14.13.39
MetaCyc1.14.13.39
UniProtKB/Swiss-Prot
Q66GP9, NOS1_ARATH;  P29475, NOS1_HUMAN;  Q9Z0J4, NOS1_MOUSE;  
O19132, NOS1_RABIT;  P29476, NOS1_RAT;  Q29498, NOS1_SHEEP;  
P35228, NOS2A_HUMAN;  P81272, NOS2B_HUMAN;  Q14961, NOS2C_HUMAN;  
Q27995, NOS2_BOVIN;  O62699, NOS2_CANFA;  Q28314, NOS2_CAPHI;  
Q92037, NOS2_CARAU;  O54705, NOS2_CAVPO;  Q90703, NOS2_CHICK;  
O46660, NOS2_MACMU;  P29477, NOS2_MOUSE;  Q92091, NOS2_ONCMY;  
P79290, NOS2_PIG;  O19114, NOS2_RABIT;  Q06518, NOS2_RAT;  
P29473, NOS3_BOVIN;  Q9TUX8, NOS3_CANFA;  P97270, NOS3_CAVPO;  
P29474, NOS3_HUMAN;  P70313, NOS3_MOUSE;  Q28969, NOS3_PIG;  
Q62600, NOS3_RAT;  P79209, NOS3_SHEEP;  O61608, NOS_ANOST;  
Q27571, NOS_DROME;  O61309, NOS_LYMST;  Q6YPG5, NOS_ORYSJ;  
Q26240, NOS_RHOPR;  Q9I9M2, NOS_SQUAC;  

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