ID   1.14.11.27
DE   [Histone H3]-lysine-36 demethylase.
AN   H3-K36-specific demethylase.
AN   Histone demethylase.
AN   Histone-lysine (H3-K36) demethylase.
AN   JHDM1A.
AN   JmjC domain-containing histone demethylase 1A.
CA   (1) Protein N(6),N(6)-dimethyl-L-lysine + 2-oxoglutarate + O(2) = protein
CA   N(6)-methyl-L-lysine + succinate + formaldehyde + CO(2).
CA   (2) Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O(2) = protein
CA   L-lysine + succinate + formaldehyde + CO(2).
CF   Fe(2+).
CC   -!- Of the seven potential methylation sites in histones H3 (K4, K9, K27,
CC       K36, K79) and H4 (K20, R3) from HeLa cells, the enzyme is specific
CC       for Lys-36.
CC   -!- Lysine residues exist in three methylation states (mono-, di- and
CC       trimethylated).
CC   -!- The enzyme preferentially demethylates the dimethyl form of Lys-36
CC       (K36me2), which is its natural substrate, to form the monomethyl and
CC       unmethylated forms of Lys-36.
CC   -!- It can also demethylate the monomethyl- but not the trimethyl form of
CC       Lys-36.
DR   Q9Y2K7, JHD1A_HUMAN;  P59997, JHD1A_MOUSE;  Q5U263, JHD1A_XENTR;
DR   Q8NHM5, JHD1B_HUMAN;  Q6P1G2, JHD1B_MOUSE;  Q640I9, JHD1B_XENLA;
DR   Q75AL5, JHD1_ASHGO ;  Q4WHB7, JHD1_ASPFU ;  Q60V67, JHD1_CAEBR ;
DR   Q95Q98, JHD1_CAEEL ;  Q5A847, JHD1_CANAL ;  Q6FPL6, JHD1_CANGA ;
DR   Q55NZ6, JHD1_CRYNE ;  Q6BXJ4, JHD1_DEBHA ;  Q9VHH9, JHD1_DROME ;
DR   Q5AW75, JHD1_EMENI ;  Q6CIC9, JHD1_KLULA ;  O94603, JHD1_SCHPO ;
DR   Q4P5U1, JHD1_USTMA ;  Q6C423, JHD1_YARLI ;  P40034, JHD1_YEAST ;
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