ID   1.13.11.52
DE   Indoleamine 2,3-dioxygenase.
AN   IDO.
AN   Tryptophan pyrrolase.
CA   (1) D-tryptophan + O(2) = N-formyl-D-kynurenine.
CA   (2) L-tryptophan + O(2) = N-formyl-L-kynurenine.
CF   Heme.
CC   -!- Requires ascorbic acid and methylene blue for activity.
CC   -!- Has broader substrate specificity than EC 1.13.11.11.
CC   -!- Is induced in response to pathological conditions and host-defense
CC       mechanisms.
CC   -!- While the enzyme is more active with D-tryptophan than L-tryptophan,
CC       its only known function to date is in the metabolism of L-tryptophan.
CC   -!- Superoxide radicals can replace O(2) as oxygen donor.
PR   PROSITE; PDOC00684;
DR   P14902, I23O_HUMAN ;  P28776, I23O_MOUSE ;  Q9ERD9, I23O_RAT   ;
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