| Official Name |
|---|
| Tryptophan 2,3-dioxygenase.
|
| Alternative Name(s) |
|---|
| Indolamine 2,3-dioxygenase. |
| Indoleamine 2,3-dioxygenase. |
| L-tryptophan 2,3-dioxygenase. |
| L-tryptophan pyrrolase. |
| Tryptamin 2,3-dioxygenase. |
| Tryptamine 2,3-dioxygenase. |
| Tryptophan oxygenase. |
| Tryptophan peroxidase. |
| Tryptophan pyrrolase. |
| Tryptophanase. |
| Reaction catalysed |
|---|
| L-tryptophan + O(2) <=> N-formyl-L-kynurenine |
| Cofactor(s) |
|---|
| Heme.
|
| Comment(s) |
|---|
- Catalyzes, together with EC 1.13.11.52, the first and rate-limiting
step in the kynurenine pathway, the major pathway of tryptophan
metabolism.
- Specific for tryptophan as substrate, but is far more active with
L-tryptophan than with D-tryptophan.
- Formerly EC 1.11.1.4 and EC 1.13.1.12.
|
| Cross-references |
|---|
| Biochemical Pathways; map number(s) | J2 |
| BRENDA | 1.13.11.11 |
| PUMA2 | 1.13.11.11 |
| PRIAM enzyme-specific profiles | 1.13.11.11 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.13.11.11 |
| IUBMB Enzyme Nomenclature | 1.13.11.11 |
| IntEnz | 1.13.11.11 |
| MEDLINE | Find literature relating to 1.13.11.11 |
| MetaCyc | 1.13.11.11 |
| UniProtKB/Swiss-Prot |
| Q2KIQ5, T23O_BOVIN; | Q09474, T23O_CAEEL; | Q7SY53, T23O_DANRE; |
| Q55DB4, T23O_DICDI; | P20351, T23O_DROME; | P48775, T23O_HUMAN; |
| P48776, T23O_MOUSE; | P21643, T23O_RAT; | Q5U4U6, T23O_XENLA; |
| Q5EBG2, T23O_XENTR; |
|
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