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NiceZyme View of ENZYME: EC 1.11.1.15

Official Name
Peroxiredoxin.
Alternative Name(s)
AhpC.
Alkyl hydroperoxide reductase C22.
PRDX.
Prx.
Thioredoxin peroxidase.
TrxPx.
Tryparedoxin peroxidase.
TXNPx.
Reaction catalysed
2 R'-SH + ROOH <=> R'-S-S-R' + H(2)O + ROH
Comment(s)
  • Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins.
  • They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins.
  • The peroxidase reaction comprises two steps centered around a redox- active cysteine called the peroxidatic cysteine.
  • All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid).
  • The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes.
  • For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants (R'-SH) (e.g. thioredoxin, AhpF, tryparedoxin or AhpD), completing the catalytic cycle.
  • In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond.
  • To recycle the disulfide, known atypical 2-Cys Prxs appear to use thioredoxin as an electron donor.
  • The 1-Cys Prxs conserve only the peroxidatic cysteine, so that its oxidized form is directly reduced to cysteine by the reductant molecule.
Cross-references
BRENDA1.11.1.15
PUMA21.11.1.15
PRIAM enzyme-specific profiles1.11.1.15
KEGG Ligand Database for Enzyme Nomenclature1.11.1.15
IUBMB Enzyme Nomenclature1.11.1.15
IntEnz1.11.1.15
MEDLINEFind literature relating to 1.11.1.15
MetaCyc1.11.1.15
UniProtKB/Swiss-Prot
O17433, 1CPX_DIRIM;  P38013, AHP1_YEAST;  P82954, AHPC_ACICA;  
P80239, AHPC_BACSU;  P83117, AHPC_COMAC;  P0AE10, AHPC_ECO57;  
P0AE09, AHPC_ECOL6;  P0AE08, AHPC_ECOLI;  P72314, AHPC_RHORU;  
P0A252, AHPC_SALTI;  P0A251, AHPC_SALTY;  P0AE11, AHPC_SHIFL;  
Q2FJN4, AHPC_STAA3;  P0A0B7, AHPC_STAA8;  Q2YVK2, AHPC_STAAB;  
Q5HIR5, AHPC_STAAC;  P0A0B5, AHPC_STAAM;  P99074, AHPC_STAAN;  
Q6GJR7, AHPC_STAAR;  Q6GC91, AHPC_STAAS;  P0A0B6, AHPC_STAAW;  
Q5HRY1, AHPC_STAEQ;  Q8CMQ2, AHPC_STAES;  Q4L376, AHPC_STAHJ;  
Q49UT8, AHPC_STAS1;  Q96291, BAS1A_ARATH;  Q9C5R8, BAS1B_ARATH;  
Q96468, BAS1_HORVU;  Q6ER94, BAS1_ORYSJ;  P84729, BAS1_PINST;  
O24364, BAS1_SPIOL;  P80602, BAS1_WHEAT;  Q9ZHF0, BCP_BUCAP;  
Q83CY8, BCP_COXBU;  P0AE54, BCP_ECO57;  P0AE53, BCP_ECOL6;  
P0AE52, BCP_ECOLI;  P44411, BCP_HAEIN;  Q9ZMU4, BCP_HELPJ;  
P55979, BCP_HELPY;  P0AE55, BCP_SHIFL;  P19476, CR29_ENTHI;  
P40553, DOT5_YEAST;  P40581, GPX3_YEAST;  P56577, MALF2_MALFU;  
P56578, MALF3_MALFU;  P0C0L2, OSMC_ECOLI;  P0C0L3, OSMC_SHIFL;  
Q9MB35, PERQ_SEDLI;  Q6UBI3, PERQ_SUASA;  O43099, PMP20_ASPFU;  
Q01116, PMP20_LIPKO;  O14313, PMP20_SCHPO;  P14292, PMPA_CANBO;  
P14293, PMPB_CANBO;  Q69TY4, PR2E1_ORYSJ;  Q7F8S5, PR2E2_ORYSJ;  
Q5E947, PRDX1_BOVIN;  Q9JKY1, PRDX1_CRIGR;  Q9V3P0, PRDX1_DROME;  
Q6DV14, PRDX1_GECJA;  Q06830, PRDX1_HUMAN;  P35700, PRDX1_MOUSE;  
Q6B4U9, PRDX1_MYOLU;  Q63716, PRDX1_RAT;  Q9BGI3, PRDX2_BOVIN;  
Q8K3U7, PRDX2_CRIGR;  P32119, PRDX2_HUMAN;  Q2PFZ3, PRDX2_MACFA;  
Q61171, PRDX2_MOUSE;  P52552, PRDX2_PIG;  Q5RC63, PRDX2_PONAB;  
P35704, PRDX2_RAT;  P35705, PRDX3_BOVIN;  P30048, PRDX3_HUMAN;  
P20108, PRDX3_MOUSE;  Q5REY3, PRDX3_PONAB;  Q9Z0V6, PRDX3_RAT;  
Q9BGI2, PRDX4_BOVIN;  Q13162, PRDX4_HUMAN;  O08807, PRDX4_MOUSE;  
Q9BGI1, PRDX5_BOVIN;  Q9GLW7, PRDX5_CERAE;  P30044, PRDX5_HUMAN;  
P99029, PRDX5_MOUSE;  Q9GLW9, PRDX5_PAPHA;  Q9R063, PRDX5_RAT;  
P83200, PRDX5_VULVU;  O77834, PRDX6_BOVIN;  Q5ZJF4, PRDX6_CHICK;  
P30041, PRDX6_HUMAN;  Q2PFL9, PRDX6_MACFA;  O08709, PRDX6_MOUSE;  
Q9TSX9, PRDX6_PIG;  Q5R7E0, PRDX6_PONAB;  O35244, PRDX6_RAT;  
Q9NL98, PRDX_ASCSU;  P34227, PRX1_YEAST;  Q7G959, PRX2A_ARATH;  
Q9XEX2, PRX2B_ARATH;  Q9SRZ4, PRX2C_ARATH;  Q9FR35, PRX2C_ORYSJ;  
O22711, PRX2D_ARATH;  Q949U7, PRX2E_ARATH;  Q9M7T0, PRX2F_ARATH;  
Q9SDD6, PRX2F_ORYSJ;  P44758, PRX5_HAEIN;  Q9LU86, PRXQ_ARATH;  
Q75SY5, PRXQ_GENTR;  P0C5D4, PRXQ_ORYSI;  P0C5D5, PRXQ_ORYSJ;  
Q6QPJ6, PRXQ_POPJC;  Q5S1S6, PRXQ_WHEAT;  O94561, PRX_SCHPO;  
P23161, R20K_CLOPA;  P0C5C8, REHYA_ORYSI;  P0C5C9, REHYA_ORYSJ;  
P0C5D0, REHYB_ORYSI;  P0C5D1, REHYB_ORYSJ;  O04005, REHY_ARATH;  
P52571, REHY_BROSE;  P52572, REHY_HORVU;  A2SZW8, REHY_MAIZE;  
Q6E2Z6, REHY_MEDTR;  P52574, REHY_TORRU;  Q6W8Q2, REHY_WHEAT;  
P48822, TDX1_BRUMA;  Q21824, TDX1_CAEEL;  Q17172, TDX2_BRUMA;  
Q6L240, TDXH1_PICTO;  Q55060, TDXH1_SULME;  Q974S8, TDXH1_SULTO;  
Q9HKX0, TDXH1_THEAC;  Q8RCY5, TDXH1_THETN;  Q6L140, TDXH2_PICTO;  
O33665, TDXH2_SULME;  Q96XS5, TDXH2_SULTO;  Q9HJL3, TDXH2_THEAC;  
Q8R844, TDXH2_THETN;  Q9Y9L0, TDXH_AERPE;  O67024, TDXH_AQUAE;  
O29969, TDXH_ARCFU;  Q8KBN8, TDXH_CHLTE;  A2BJD9, TDXH_HYPBU;  
A8A9P0, TDXH_IGNH4;  Q58146, TDXH_METJA;  A4FWZ9, TDXH_METM5;  
Q8PYP6, TDXH_METMA;  Q6LY19, TDXH_METMP;  O26262, TDXH_METTH;  
Q57109, TDXH_METTM;  A6UPH7, TDXH_METVS;  Q74NC6, TDXH_NANEQ;  
Q9UZV4, TDXH_PYRAB;  Q8U218, TDXH_PYRFU;  O58966, TDXH_PYRHO;  
Q5JF30, TDXH_PYRKO;  A3DKL1, TDXH_STAMF;  P95895, TDXH_SULSO;  
Q9WZR4, TDXH_THEMA;  A5IIX7, TDXH_THEP1;  Q979N7, TDXH_THEVO;  
Q73RS4, TDXH_TREDE;  Q90384, TDX_CYNPY;  Q8T6C4, TDX_ECHGR;  
P91883, TDX_FASHE;  Q91191, TDX_ONCMY;  Q26695, TDX_TRYBR;  
Q9Y7F0, TSA1_CANAL;  P34760, TSA1_YEAST;  Q04120, TSA2_YEAST;  
P57279, TSAA_BUCAI;  Q8K9W0, TSAA_BUCAP;  Q89AS1, TSAA_BUCBP;  
P56876, TSAA_HELPJ;  P21762, TSAA_HELPY;  P52570, TSA_ONCVO;  
P73728, Y1621_SYNY3;  P65688, Y2238_MYCTU;  P65689, Y2262_MYCBO;  
Q53212, Y4VD_RHISN;  Q55624, Y755_SYNY3;  P49537, YCF42_ODOSI;  
P51272, YCF42_PORPU;  Q1XDL4, YCF42_PORYE;  P26830, YNDH_BACYN;  
O69777, YRP2_RHIET;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.11.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.11.-.-
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