| Official Name |
|---|
| 2,5-didehydrogluconate reductase.
|
| Alternative Name(s) |
|---|
| 2,5-diketo-D-gluconate reductase. |
| Reaction catalysed |
|---|
| 2-dehydro-D-gluconate + NADP(+) <=> 2,5-didehydro-D-gluconate + NADPH |
| Comment(s) |
|---|
- Key enzyme in the microbial production of ascorbate.
- Can also reduce ethyl 2-methylacetoacetate stereoselectively to ethyl
(2R)-methyl-(3S)-hydroxybutanoate and can also accept some other
beta-keto esters.
- The identification of a bacterial beta-keto ester reductase as a 2,5-
didehydrogluconate reductase links two previously separate areas of
biocatalysis, i.e., asymmetric carbonyl reduction and microbial
vitamin C production.
|
| Cross-references |
|---|
| PROSITE | PDOC00061 |
| BRENDA | 1.1.1.274 |
| PUMA2 | 1.1.1.274 |
| PRIAM enzyme-specific profiles | 1.1.1.274 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.274 |
| IUBMB Enzyme Nomenclature | 1.1.1.274 |
| IntEnz | 1.1.1.274 |
| MEDLINE | Find literature relating to 1.1.1.274 |
| MetaCyc | 1.1.1.274 |
| UniProtKB/Swiss-Prot |
| P06632, DKGA_CORSC; | Q8XBT6, DKGA_ECO57; | Q46857, DKGA_ECOLI; |
| P58744, DKGA_SALTI; | Q8ZM06, DKGA_SALTY; | Q8ZI40, DKGA_YERPE; |
| P15339, DKGB_CORSS; | Q8X7Z7, DKGB_ECO57; | P30863, DKGB_ECOLI; |
| Q8Z988, DKGB_SALTI; | Q8ZRM7, DKGB_SALTY; | Q8ZH36, DKGB_YERPE; |
|
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