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NiceZyme View of ENZYME: EC 1.1.1.206

Official Name
Tropinone reductase I.
Alternative Name(s)
TR-I.
Tropine dehydrogenase.
Tropinone reductase.
Reaction catalysed
Tropine + NADP(+) <=> tropinone + NADPH
Comment(s)
  • Also oxidizes other tropan-3-alpha-ols, but not the corresponding beta-derivatives.
  • Represents, along with EC 1.1.1.236, a branch point in tropane alkaloid metabolism.
  • Tropine (the product of EC 1.1.1.206) is incorporated into hyoscyamine and scopolamine whereas pseudotropine (the product of EC 1.1.1.236) is the first specific metabolite on the pathway to the calystegines.
  • Both enzymes are always found together in any given tropane-alkaloid- producing species, have a common substrate, tropinone, and are strictly stereospecific.
Cross-references
PROSITEPDOC00060
BRENDA1.1.1.206
PUMA21.1.1.206
PRIAM enzyme-specific profiles1.1.1.206
KEGG Ligand Database for Enzyme Nomenclature1.1.1.206
IUBMB Enzyme Nomenclature1.1.1.206
IntEnz1.1.1.206
MEDLINEFind literature relating to 1.1.1.206
MetaCyc1.1.1.206
UniProtKB/Swiss-Prot
P50162, TRN1_DATST

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